Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools

Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools

BackgroundImputation has become a standard approach in genome-wide association studies (GWAS) to infer in silico untyped markers. Although feasibility for common variants imputation is well established, we aimed to assess rare and ultra-rare variants’ imputation in an admixed Caribbean Hispanic popu...

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Bibliographic Details
Main Authors: Sanjeev Sariya, Joseph H. Lee, Richard Mayeux, Badri N. Vardarajan, Dolly Reyes-Dumeyer, Jennifer J. Manly, Adam M. Brickman, Rafael Lantigua, Martin Medrano, Ivonne Z. Jimenez-Velazquez, Giuseppe Tosto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
rare variants
imputation
admixed population
GWAS
1000G
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00239/full

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