A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19
Background: The incidence of venous thromboembolic events (VTE) in patients with COVID-19 is generally high but varies markedly. However, the relationship between anticoagulation and mortality in patients with COVID-19 is still unclear. Methods: We performed a systematic review and meta-analysis to...
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doaj-f4505ee173174559ac428b64b1fcc3ec2020-11-25T03:41:48ZengElsevierInternational Journal of Infectious Diseases1201-97122020-11-011003441A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19Ying-feng Lu0Li-ya Pan1Wen-Wu Zhang2Fang Cheng3Sha-Sha Hu4Xue Zhang5Hai-yin Jiang6Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Child and Adolescent Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang, ChinaDepartment of Child and Adolescent Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang, ChinaDepartment of Child and Adolescent Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Corresponding author.Background: The incidence of venous thromboembolic events (VTE) in patients with COVID-19 is generally high but varies markedly. However, the relationship between anticoagulation and mortality in patients with COVID-19 is still unclear. Methods: We performed a systematic review and meta-analysis to determine the incidence of VTE and evaluate the role of anticoagulation in patients with COVID-19. Random effects models were used to determine overall pooled estimates and 95% confidence intervals (CIs). Results: After a database search, 25 observational studies (20 on VTE incidence and 5 on the relationship between anticoagulation and mortality) were included. The pooled incidence rates of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in hospitalised COVID-19 patients were 21% (95% CI 15–27%), 15% (95% CI 10–20%), and 27% (95% CI 19–36%), respectively. A meta-analysis of five studies found that anticoagulation was not associated with an increased risk of mortality in hospitalised COVID-19 patients (RR = 0.86, 95% CI, 0.69–1.09, P = 0.218; I2 = 47.4%). Conclusions: In conclusion, the incidence of VTE among hospitalised COVID-19 patients was high. Clinical trials are urgently needed to evaluate the roles of prophylactic and therapeutic anticoagulation in COVID-19.http://www.sciencedirect.com/science/article/pii/S1201971220306524COVID-19CoagulationAntithromboticHeparin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying-feng Lu Li-ya Pan Wen-Wu Zhang Fang Cheng Sha-Sha Hu Xue Zhang Hai-yin Jiang |
spellingShingle |
Ying-feng Lu Li-ya Pan Wen-Wu Zhang Fang Cheng Sha-Sha Hu Xue Zhang Hai-yin Jiang A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19 International Journal of Infectious Diseases COVID-19 Coagulation Antithrombotic Heparin |
author_facet |
Ying-feng Lu Li-ya Pan Wen-Wu Zhang Fang Cheng Sha-Sha Hu Xue Zhang Hai-yin Jiang |
author_sort |
Ying-feng Lu |
title |
A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19 |
title_short |
A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19 |
title_full |
A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19 |
title_fullStr |
A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19 |
title_full_unstemmed |
A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19 |
title_sort |
meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with covid-19 |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2020-11-01 |
description |
Background: The incidence of venous thromboembolic events (VTE) in patients with COVID-19 is generally high but varies markedly. However, the relationship between anticoagulation and mortality in patients with COVID-19 is still unclear. Methods: We performed a systematic review and meta-analysis to determine the incidence of VTE and evaluate the role of anticoagulation in patients with COVID-19. Random effects models were used to determine overall pooled estimates and 95% confidence intervals (CIs). Results: After a database search, 25 observational studies (20 on VTE incidence and 5 on the relationship between anticoagulation and mortality) were included. The pooled incidence rates of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in hospitalised COVID-19 patients were 21% (95% CI 15–27%), 15% (95% CI 10–20%), and 27% (95% CI 19–36%), respectively. A meta-analysis of five studies found that anticoagulation was not associated with an increased risk of mortality in hospitalised COVID-19 patients (RR = 0.86, 95% CI, 0.69–1.09, P = 0.218; I2 = 47.4%). Conclusions: In conclusion, the incidence of VTE among hospitalised COVID-19 patients was high. Clinical trials are urgently needed to evaluate the roles of prophylactic and therapeutic anticoagulation in COVID-19. |
topic |
COVID-19 Coagulation Antithrombotic Heparin |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220306524 |
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