Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities
Alongside their function in primary hemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and it...
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doaj-f45316daafd748ceb7a9fe4ed79a32c12020-11-25T04:11:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-01218817881710.3390/ijms21228817Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-MorbiditiesBenedetta Izzi0Alfonsina Tirozzi1Chiara Cerletti2Maria Benedetta Donati3Giovanni de Gaetano4Marc F Hoylaerts5Licia Iacoviello6Alessandro Gialluisi7Department of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, ItalyDepartment of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, ItalyDepartment of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, ItalyDepartment of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, ItalyDepartment of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, ItalyDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, 3000 Leuven, BelgiumDepartment of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, ItalyDepartment of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, ItalyAlongside their function in primary hemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic.https://www.mdpi.com/1422-0067/21/22/8817depressionplateletscardiovascular diseasepsychiatric comorbiditiesneurodegenerative disordersplatelet distribution width |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benedetta Izzi Alfonsina Tirozzi Chiara Cerletti Maria Benedetta Donati Giovanni de Gaetano Marc F Hoylaerts Licia Iacoviello Alessandro Gialluisi |
spellingShingle |
Benedetta Izzi Alfonsina Tirozzi Chiara Cerletti Maria Benedetta Donati Giovanni de Gaetano Marc F Hoylaerts Licia Iacoviello Alessandro Gialluisi Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities International Journal of Molecular Sciences depression platelets cardiovascular disease psychiatric comorbidities neurodegenerative disorders platelet distribution width |
author_facet |
Benedetta Izzi Alfonsina Tirozzi Chiara Cerletti Maria Benedetta Donati Giovanni de Gaetano Marc F Hoylaerts Licia Iacoviello Alessandro Gialluisi |
author_sort |
Benedetta Izzi |
title |
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities |
title_short |
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities |
title_full |
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities |
title_fullStr |
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities |
title_full_unstemmed |
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities |
title_sort |
beyond haemostasis and thrombosis: platelets in depression and its co-morbidities |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-11-01 |
description |
Alongside their function in primary hemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic. |
topic |
depression platelets cardiovascular disease psychiatric comorbidities neurodegenerative disorders platelet distribution width |
url |
https://www.mdpi.com/1422-0067/21/22/8817 |
work_keys_str_mv |
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