The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk
Background: The goal of this study was to assess the oxidative stress status through the values of antioxidant defense parameters: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS), as well as cardiovascular risk factors (total ch...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Society of Medical Biochemists of Serbia, Belgrade
2020-01-01
|
Series: | Journal of Medical Biochemistry |
Subjects: | |
Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582003346Q.pdf |
id |
doaj-f4547edc0e2f4f00bcf8a075d34b904b |
---|---|
record_format |
Article |
spelling |
doaj-f4547edc0e2f4f00bcf8a075d34b904b2020-11-25T02:38:14ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662020-01-013933463541452-82582003346QThe impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular riskČolak Emina0Pap Dragana1Nikolić Ljubinka2Vicković Sanja3University of Belgrade, Clinical Center of Serbia and School of Pharmacy, Institute of Medical BiochemistryInstitute for the Health Protection of Students, Department of Laboratory Diagnostics, Novi SadClinical Center of Serbia, Department for Hematology and Transfusion Laboratory, Clinic for Gynecology and ObstetricsUniversity of Novi Sad, Clinical Center of Vojvodina and School of Medicine, Department of Anesthesiology and Intensive CareBackground: The goal of this study was to assess the oxidative stress status through the values of antioxidant defense parameters: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS), as well as cardiovascular risk factors (total cholesterol, LDL-cholesterol, VLDL-cholesterol, non-HDL-cholesterol and triglycerides), anthropometric parameters (Body mass index-BMI, waist circumference-WC, hipp circumferemce-HC, waist-to-hipp ratio-WHR and inflammatory markers (high sensitive C-reactive protein) in a group of obese adolescents. Methods: A total of 238 students of both sexes, age of 22.32 ± 1.85 yr. were included in the study. According to the values of BMI lower and higher than 25 kg/m2 and WC higher and lower than 94 cm (males)/80 cm (females) the tested group of students was divided into 2 subgroups: Group 1 (increased risk for CVD) and Group 2 (lower risk for CVD). Results: Significantly reduced SOD and GPx with increased GR, TAS, inflammatory and lipoprotein parameters were obtained in Group 1 compared to Group 2. Significant positive association of hsCRP (OR:1.41; 95%CI 1.08-1.83; P=0.007), TAS (OR:827.2; 95%CI 19.27-35498; P=0.007) and GR (OR:1.13; 95%CI 1.05-1.21; P=0.002) and negative association of GPx (OR:0.97; 95%CI 0.94-1.003; P=0.043) and HDL-cholesterol (OR:0.41; 95%CI 0.176-0.963; P=0.0014) with cardiovascular risk factors were found in obese students. According to the ROC analysis GR>44.8 U/L, TAS>1.35 mmol/L, hsCRP>1.71 mg/L and HDL-cholesterol <1.13 mmol/L have sufficient predictive ability for cardiovascular disease in obese students. Conclusions: Significant association of antioxidant defense parameters with anthropometric, lipid and inflammatory markers in obese students with increased cardiovascular risk suggest that screening of these parameters is necessary and highly recommended.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582003346Q.pdfobesityoxidative stressantioxidant defensecardiovascular risk factorsinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Čolak Emina Pap Dragana Nikolić Ljubinka Vicković Sanja |
spellingShingle |
Čolak Emina Pap Dragana Nikolić Ljubinka Vicković Sanja The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk Journal of Medical Biochemistry obesity oxidative stress antioxidant defense cardiovascular risk factors inflammation |
author_facet |
Čolak Emina Pap Dragana Nikolić Ljubinka Vicković Sanja |
author_sort |
Čolak Emina |
title |
The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_short |
The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_full |
The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_fullStr |
The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_full_unstemmed |
The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_sort |
impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
publisher |
Society of Medical Biochemists of Serbia, Belgrade |
series |
Journal of Medical Biochemistry |
issn |
1452-8258 1452-8266 |
publishDate |
2020-01-01 |
description |
Background: The goal of this study was to assess the oxidative stress status through the values of antioxidant defense parameters: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS), as well as cardiovascular risk factors (total cholesterol, LDL-cholesterol, VLDL-cholesterol, non-HDL-cholesterol and triglycerides), anthropometric parameters (Body mass index-BMI, waist circumference-WC, hipp circumferemce-HC, waist-to-hipp ratio-WHR and inflammatory markers (high sensitive C-reactive protein) in a group of obese adolescents. Methods: A total of 238 students of both sexes, age of 22.32 ± 1.85 yr. were included in the study. According to the values of BMI lower and higher than 25 kg/m2 and WC higher and lower than 94 cm (males)/80 cm (females) the tested group of students was divided into 2 subgroups: Group 1 (increased risk for CVD) and Group 2 (lower risk for CVD). Results: Significantly reduced SOD and GPx with increased GR, TAS, inflammatory and lipoprotein parameters were obtained in Group 1 compared to Group 2. Significant positive association of hsCRP (OR:1.41; 95%CI 1.08-1.83; P=0.007), TAS (OR:827.2; 95%CI 19.27-35498; P=0.007) and GR (OR:1.13; 95%CI 1.05-1.21; P=0.002) and negative association of GPx (OR:0.97; 95%CI 0.94-1.003; P=0.043) and HDL-cholesterol (OR:0.41; 95%CI 0.176-0.963; P=0.0014) with cardiovascular risk factors were found in obese students. According to the ROC analysis GR>44.8 U/L, TAS>1.35 mmol/L, hsCRP>1.71 mg/L and HDL-cholesterol <1.13 mmol/L have sufficient predictive ability for cardiovascular disease in obese students. Conclusions: Significant association of antioxidant defense parameters with anthropometric, lipid and inflammatory markers in obese students with increased cardiovascular risk suggest that screening of these parameters is necessary and highly recommended. |
topic |
obesity oxidative stress antioxidant defense cardiovascular risk factors inflammation |
url |
https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582003346Q.pdf |
work_keys_str_mv |
AT colakemina theimpactofobesitytoantioxidantdefenseparametersinadolescentswithincreasedcardiovascularrisk AT papdragana theimpactofobesitytoantioxidantdefenseparametersinadolescentswithincreasedcardiovascularrisk AT nikolicljubinka theimpactofobesitytoantioxidantdefenseparametersinadolescentswithincreasedcardiovascularrisk AT vickovicsanja theimpactofobesitytoantioxidantdefenseparametersinadolescentswithincreasedcardiovascularrisk AT colakemina impactofobesitytoantioxidantdefenseparametersinadolescentswithincreasedcardiovascularrisk AT papdragana impactofobesitytoantioxidantdefenseparametersinadolescentswithincreasedcardiovascularrisk AT nikolicljubinka impactofobesitytoantioxidantdefenseparametersinadolescentswithincreasedcardiovascularrisk AT vickovicsanja impactofobesitytoantioxidantdefenseparametersinadolescentswithincreasedcardiovascularrisk |
_version_ |
1724792073613213696 |