Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial
ObjectiveWe investigated if a 5-week computerized adaptive working memory training program (Cogmed®) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions compared to a non-adaptive working memory training program (active-controlled)...
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doaj-f45cfc40563e44adab189abe7ddb7a5f2020-11-24T20:40:30ZengFrontiers Media S.A.Frontiers in Psychology1664-10782019-04-011010.3389/fpsyg.2019.00807440208Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled TrialMarianne M. Flak0Marianne M. Flak1Haakon R. Hol2Haakon R. Hol3Susanne S. Hernes4Susanne S. Hernes5Linda Chang6Linda Chang7Andreas Engvig8Knut Jørgen Bjuland9Are Pripp10Bengt-Ove Madsen11Anne-Brita Knapskog12Ingun Ulstein13Trine Lona14Jon Skranes15Jon Skranes16Gro C. C. Løhaugen17Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Pediatrics, Sørlandet Hospital HF, Arendal, NorwayDepartment of Radiology, Sørlandet Hospital HF, Arendal, NorwayDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Medicine, The Memory Clinic Geriatric Unit, Sørlandet Hospital, Arendal, NorwayDepartment of Diagnostic Radiology and Nuclear Medicine, and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United StatesDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Medicine, Diakonhjemmet Hospital, Oslo, NorwayDepartment of Research, Sørlandet Hospital, Arendal, Norway0Oslo Centre of Biostatistics and Epidemiology Research Support Services, Oslo University Hospital, Oslo, NorwayDepartment of Medicine, The Memory Clinic Geriatric Unit, Sørlandet Hospital, Arendal, Norway1Department of Geriatric Medicine, The Memory Clinic, Oslo University Hospital, Oslo, Norway1Department of Geriatric Medicine, The Memory Clinic, Oslo University Hospital, Oslo, Norway2Department of Psychiatry, Age Psychiatry, The Hospital of Telemark, Skien, NorwayDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Pediatrics, Sørlandet Hospital HF, Arendal, NorwayDepartment of Pediatrics, Sørlandet Hospital HF, Arendal, NorwayObjectiveWe investigated if a 5-week computerized adaptive working memory training program (Cogmed®) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions compared to a non-adaptive working memory training program (active-controlled) in adult patients with mild cognitive impairment (MCI).MethodsThis randomized double-blinded active control trial included 68 individuals aged 43 to 88 years, 45 men and 23 women, who were diagnosed with MCI at four Memory clinics. The study sample was randomized by block randomization to either adaptive or non-adaptive computerized working memory training. All participants completed the training, and were assessed with a comprehensive neuropsychological test battery before the intervention, and at 1 and 4 months after training.ResultsCompared to the non-adaptive training group, the adaptive training group did not show significantly greater improvement on the main outcome of working memory performance at 1 and 4 months after training.ConclusionNo difference were found between the two types of training on the primary outcome of working memory, or on secondary outcomes of cognitive function domains, in this sample of MCI patients. Hence, the hypothesis that the adaptive training program would lead to greater improvements compared to the non-adaptive training program was not supported. Within group analyses was not performed due to the stringent RCT design.https://www.frontiersin.org/article/10.3389/fpsyg.2019.00807/fullcomputerized cognitive trainingworking memorymild cognitive impairment (MCI)neuropsychological outcomesrandomized controlled trial (RCT) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marianne M. Flak Marianne M. Flak Haakon R. Hol Haakon R. Hol Susanne S. Hernes Susanne S. Hernes Linda Chang Linda Chang Andreas Engvig Knut Jørgen Bjuland Are Pripp Bengt-Ove Madsen Anne-Brita Knapskog Ingun Ulstein Trine Lona Jon Skranes Jon Skranes Gro C. C. Løhaugen |
spellingShingle |
Marianne M. Flak Marianne M. Flak Haakon R. Hol Haakon R. Hol Susanne S. Hernes Susanne S. Hernes Linda Chang Linda Chang Andreas Engvig Knut Jørgen Bjuland Are Pripp Bengt-Ove Madsen Anne-Brita Knapskog Ingun Ulstein Trine Lona Jon Skranes Jon Skranes Gro C. C. Løhaugen Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial Frontiers in Psychology computerized cognitive training working memory mild cognitive impairment (MCI) neuropsychological outcomes randomized controlled trial (RCT) |
author_facet |
Marianne M. Flak Marianne M. Flak Haakon R. Hol Haakon R. Hol Susanne S. Hernes Susanne S. Hernes Linda Chang Linda Chang Andreas Engvig Knut Jørgen Bjuland Are Pripp Bengt-Ove Madsen Anne-Brita Knapskog Ingun Ulstein Trine Lona Jon Skranes Jon Skranes Gro C. C. Løhaugen |
author_sort |
Marianne M. Flak |
title |
Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial |
title_short |
Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial |
title_full |
Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial |
title_fullStr |
Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial |
title_full_unstemmed |
Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial |
title_sort |
adaptive computerized working memory training in patients with mild cognitive impairment. a randomized double-blind active controlled trial |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychology |
issn |
1664-1078 |
publishDate |
2019-04-01 |
description |
ObjectiveWe investigated if a 5-week computerized adaptive working memory training program (Cogmed®) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions compared to a non-adaptive working memory training program (active-controlled) in adult patients with mild cognitive impairment (MCI).MethodsThis randomized double-blinded active control trial included 68 individuals aged 43 to 88 years, 45 men and 23 women, who were diagnosed with MCI at four Memory clinics. The study sample was randomized by block randomization to either adaptive or non-adaptive computerized working memory training. All participants completed the training, and were assessed with a comprehensive neuropsychological test battery before the intervention, and at 1 and 4 months after training.ResultsCompared to the non-adaptive training group, the adaptive training group did not show significantly greater improvement on the main outcome of working memory performance at 1 and 4 months after training.ConclusionNo difference were found between the two types of training on the primary outcome of working memory, or on secondary outcomes of cognitive function domains, in this sample of MCI patients. Hence, the hypothesis that the adaptive training program would lead to greater improvements compared to the non-adaptive training program was not supported. Within group analyses was not performed due to the stringent RCT design. |
topic |
computerized cognitive training working memory mild cognitive impairment (MCI) neuropsychological outcomes randomized controlled trial (RCT) |
url |
https://www.frontiersin.org/article/10.3389/fpsyg.2019.00807/full |
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