Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection

Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection

Abstract Bovine leukemia virus (BLV) is a retrovirus that infects B cells in cattle and causes bovine leukosis after a long latent period. Progressive exhaustion of T cell functions is considered to facilitate disease progression of BLV infection. Programmed death-1 (PD-1) and lymphocyte activation...

Full description

Bibliographic Details
Main Authors:	Tomohiro Okagawa, Satoru Konnai, Asami Nishimori, Naoya Maekawa, Shinya Goto, Ryoyo Ikebuchi, Junko Kohara, Yasuhiko Suzuki, Shinji Yamada, Yukinari Kato, Shiro Murata, Kazuhiko Ohashi
Format:	Article
Language:	English
Published:	BMC 2018-06-01
Series:	Veterinary Research
Online Access:	http://link.springer.com/article/10.1186/s13567-018-0543-9

Similar Items

In vitro and in vivo antivirus activity of an anti-programmed death-ligand 1 (PD-L1) rat-bovine chimeric antibody against bovine leukemia virus infection.
by: Asami Nishimori, et al.
Published: (2017-01-01)

Anti-Bovine Programmed Death-1 Rat–Bovine Chimeric Antibody for Immunotherapy of Bovine Leukemia Virus Infection in Cattle
by: Tomohiro Okagawa, et al.
Published: (2017-06-01)

Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.
by: Naoya Maekawa, et al.
Published: (2016-01-01)

Expression of PD-L1 on canine tumor cells and enhancement of IFN-γ production from tumor-infiltrating cells by PD-L1 blockade.
by: Naoya Maekawa, et al.
Published: (2014-01-01)

Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production
by: Kei Watari, et al.
Published: (2019-10-01)

A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma
by: Naoya Maekawa, et al.
Published: (2017-08-01)

Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection
by: Okagawa Tomohiro, et al.
Published: (2012-05-01)

Effects of bovine tumor necrosis factor alpha decoy receptors on cell death and inflammatory cytokine kinetics: potential for bovine inflammation therapy
by: Sotaro Fujisawa, et al.
Published: (2019-02-01)

Research Note: Characterization of S-Meq containing the deletion in Meq protein's transactivation domain in a Marek's disease virus strain in Japan
by: Shiro Murata, et al.
Published: (2021-11-01)

The Suppression of Th1 Response by Inducing TGF-β1 From Regulatory T Cells in Bovine Mycoplasmosis
by: Yamato Sajiki, et al.
Published: (2020-12-01)

Expression Analysis of Canine CMTM6 and CMTM4 as Potential Regulators of the PD-L1 Protein in Canine Cancers
by: Hiroto Takeuchi, et al.
Published: (2020-06-01)

Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade
by: Ikebuchi Ryoyo, et al.
Published: (2011-09-01)

Canine Transforming Growth Factor-β Receptor 2-Ig: A Potential Candidate Biologic for Melanoma Treatment That Reverses Transforming Growth Factor-β1 Immunosuppression
by: Hiroto Takeuchi, et al.
Published: (2021-06-01)

Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection
by: Shinya Goto, et al.
Published: (2020-02-01)

PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade.
by: Otgontuya Ganbaatar, et al.
Published: (2020-01-01)

Characterisation of a cysteine protease from poultry red mites and its potential use as a vaccine for chickens
by: Murata Shiro, et al.
Published: (2021-01-01)

PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma
by: Naoya Maekawa, et al.
Published: (2021-02-01)

Molecular Epidemiology and Whole-Genome Analysis of Bovine Foamy Virus in Japan
by: Hirohisa Mekata, et al.
Published: (2021-05-01)

The mouse–canine chimeric anti-dog podoplanin antibody P38B exerts antitumor activity in mouse xenograft models
by: Yukinari Kato, et al.
Published: (2019-03-01)

Haematophagous mites on poultry farms in the Republic of the Union of Myanmar
by: Masaki Takehara, et al.
Published: (2019-04-01)

Early Growth Response Gene 2-Expressing CD4+LAG3+ Regulatory T Cells: The Therapeutic Potential for Treating Autoimmune Diseases
by: Tomohisa Okamura, et al.
Published: (2018-02-01)

Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma.
by: Michihito Tagawa, et al.
Published: (2016-01-01)

Tick saliva-induced programmed death-1 and PD-ligand 1 and its related host immunosuppression
by: Yamato Sajiki, et al.
Published: (2021-01-01)

CD4+CD25+LAG3+ T Cells With a Feature of Th17 Cells Associated With Systemic Lupus Erythematosus Disease Activity
by: Rika Kato, et al.
Published: (2019-07-01)

Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in chickens infected with Marek’s disease virus
by: Matsuyama-Kato Ayumi, et al.
Published: (2012-05-01)

Epitope mapping of anti-mouse podoplanin monoclonal antibody PMab-1
by: Shinji Yamada, et al.
Published: (2018-09-01)

Functional Phenotypic Diversity of Regulatory T Cells Remaining in Inflamed Skin
by: Ryoyo Ikebuchi, et al.
Published: (2019-05-01)

Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells.
by: Suresh Pallikkuth, et al.
Published: (2018-01-01)

Intrapelvic Migration of the Lag Screw in Intramedullary Nailing
by: Tomoya Takasago, et al.
Published: (2014-01-01)

LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma
by: Niklas Klümper, et al.
Published: (2020-06-01)

Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo.
by: Nicholas M Durham, et al.
Published: (2014-01-01)

CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon-γ Production In Vivo.
by: Takeshi Kurihara, et al.
Published: (2015-01-01)

CD49b/CD69-dependent generation of resting T helper cell memory
by: Asami eHanazawa, et al.
Published: (2013-07-01)

Detection of high CD44 expression in oral cancers using the novel monoclonal antibody, C44Mab-5
by: Shinji Yamada, et al.
Published: (2018-07-01)

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.
by: Rémi Fromentin, et al.
Published: (2016-07-01)

LAG3 and PD1 Regulate CD8+ T Cell in Diffuse Large B-cell Lymphoma Patients
by: Ying Liu, et al.
Published: (2021-01-01)

Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging.
by: Maria Gerasimenko, et al.
Published: (2020-01-01)

Administration of an antigen at a high dose generates regulatory CD4^+T cells expressing CD95 ligand and secreting IL-4 in the liver
by: Watanabe, Tomohiro
Published: (2011)

Dynamic Changes in the Phenotype of Dendritic Cells in the Uterus and Uterine Draining Lymph Nodes After Coitus
by: Ippei Yasuda, et al.
Published: (2020-09-01)

CD40 activation rescues antiviral CD8⁺ T cells from PD-1-mediated exhaustion.
by: Masanori Isogawa, et al.
Published: (2013-01-01)