Astragali Radix Isoflavones Synergistically Alleviate Cerebral Ischemia and Reperfusion Injury Via Activating Estrogen Receptor-PI3K-Akt Signaling Pathway

Astragali Radix Isoflavones Synergistically Alleviate Cerebral Ischemia and Reperfusion Injury Via Activating Estrogen Receptor-PI3K-Akt Signaling Pathway

Isoflavones are major neuroprotective components of a medicinal herb Astragali Radix, against cerebral ischemia-reperfusion injury but the mechanisms of neuroprotection remain unclear. Calycosin and formononetin are two major AR isoflavones while daidzein is the metabolite of formononetin after abso...

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Bibliographic Details
Main Authors:	Yong Gu, Xi Chen, Shuping Fu, Wenlan Liu, Qi Wang, Ke-Jian Liu, Jiangang Shen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Pharmacology
Subjects:	astragali radix estrogen receptor synergism isoflavones neuroprotection
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.533028/full

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