Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface
Abstract Betulin (BE) has exceedingly become a potential natural product, providing multiple pharmacological and biological activities, including anti-cancer, anti-viral, and anti-inflammatory benefits. Previous research indicated that the solvatomorphism of BE can easily occur through crystallizati...
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doaj-f4695d85306b42b6a4e13b8cc97e53022021-05-16T11:12:52ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092020-05-0110314115210.1007/s13659-020-00243-3Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type InterfacePeng-Hui Yuan0Yan-Cai Bi1Bin Su2De-Zhi Yang3Ning-Bo Gong4Li Zhang5Yang Lu6Guan-Hua Du7Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeSoteria Pharmaceutical Co., LtdSoteria Pharmaceutical Co., LtdBeijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing City Key Laboratory of Drug Target and Screening Research, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Betulin (BE) has exceedingly become a potential natural product, providing multiple pharmacological and biological activities, including anti-cancer, anti-viral, and anti-inflammatory benefits. Previous research indicated that the solvatomorphism of BE can easily occur through crystallization with different organic solvents. This property of BE can directly affect its extraction, isolation, and preparation process. In this study, a system of thermogravimetry (TG)–differential thermal analysis (DTA) coupled with mass spectrometry (MS) with electron ionization (EI) and photoionization (PI) capability, equipped with the skimmer-type interface (i.e., skimmer-type interfaced TG–DTA–EI/PI–MS system), as a real-time and onsite analysis technique, was employed. Then, four solvatomorphs of BE, namely, with pyridine and water (A), sec-butanol (B), n,n-dimethylformamide (DMF) (C), and isopropanol (V), were analyzed for the first time. Finally, five kinds of the main volatile gaseous species, including H2O, pyridine, sec-butanol, DMF, and isopropanol, were identified clearly. Furthermore, the multi-step desolvation processes of the four solvatomorphs of BE were revealed by this system for the first time. This system showed great potential for the rapid and accurate analysis of various solvatomorphs of natural products. Graphic Abstracthttps://doi.org/10.1007/s13659-020-00243-3BetulinSolvatomorphsTG–MSPI method |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peng-Hui Yuan Yan-Cai Bi Bin Su De-Zhi Yang Ning-Bo Gong Li Zhang Yang Lu Guan-Hua Du |
spellingShingle |
Peng-Hui Yuan Yan-Cai Bi Bin Su De-Zhi Yang Ning-Bo Gong Li Zhang Yang Lu Guan-Hua Du Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface Natural Products and Bioprospecting Betulin Solvatomorphs TG–MS PI method |
author_facet |
Peng-Hui Yuan Yan-Cai Bi Bin Su De-Zhi Yang Ning-Bo Gong Li Zhang Yang Lu Guan-Hua Du |
author_sort |
Peng-Hui Yuan |
title |
Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface |
title_short |
Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface |
title_full |
Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface |
title_fullStr |
Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface |
title_full_unstemmed |
Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface |
title_sort |
analysis of four solvatomorphs of betulin by tg–dta–ei/pi–ms system equipped with the skimmer-type interface |
publisher |
SpringerOpen |
series |
Natural Products and Bioprospecting |
issn |
2192-2195 2192-2209 |
publishDate |
2020-05-01 |
description |
Abstract Betulin (BE) has exceedingly become a potential natural product, providing multiple pharmacological and biological activities, including anti-cancer, anti-viral, and anti-inflammatory benefits. Previous research indicated that the solvatomorphism of BE can easily occur through crystallization with different organic solvents. This property of BE can directly affect its extraction, isolation, and preparation process. In this study, a system of thermogravimetry (TG)–differential thermal analysis (DTA) coupled with mass spectrometry (MS) with electron ionization (EI) and photoionization (PI) capability, equipped with the skimmer-type interface (i.e., skimmer-type interfaced TG–DTA–EI/PI–MS system), as a real-time and onsite analysis technique, was employed. Then, four solvatomorphs of BE, namely, with pyridine and water (A), sec-butanol (B), n,n-dimethylformamide (DMF) (C), and isopropanol (V), were analyzed for the first time. Finally, five kinds of the main volatile gaseous species, including H2O, pyridine, sec-butanol, DMF, and isopropanol, were identified clearly. Furthermore, the multi-step desolvation processes of the four solvatomorphs of BE were revealed by this system for the first time. This system showed great potential for the rapid and accurate analysis of various solvatomorphs of natural products. Graphic Abstract |
topic |
Betulin Solvatomorphs TG–MS PI method |
url |
https://doi.org/10.1007/s13659-020-00243-3 |
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