Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy

• Main Authors: Ping Gong, Yifan Wang, Pengfei Zhang, Zhaogang Yang, Weiye Deng, Zhihong Sun, Mingming Yang, Xuefeng Li, Gongcheng Ma, Guanjun Deng, Shiyan Dong, Lintao Cai, Wen Jiang
• Format: Article
• Language: English
• Published: MDPI AG 2021-12-01
• Series: Cancers
• Subjects: immunocyte membrane-coated nanoparticles; biomimicry; cancer immunotherapy; macrophage; T-cell; natural killer
• Online Access: https://www.mdpi.com/2072-6694/13/1/77

Despite the advances in surface bioconjugation of synthetic nanoparticles for targeted drug delivery, simple biological functionalization is still insufficient to replicate complex intercellular interactions naturally. Therefore, these foreign nanoparticles are inevitably exposed to the immune system, which results in phagocytosis by the reticuloendothelial system and thus, loss of their biological significance. Immunocyte membranes play a key role in intercellular interactions, and can protect foreign nanomaterials as a natural barrier. Therefore, biomimetic nanotechnology based on cell membranes has developed rapidly in recent years. This paper summarizes the development of immunocyte membrane-coated nanoparticles in the immunotherapy of tumors. We will introduce several immunocyte membrane-coated nanocarriers and review the challenges to their large-scale preparation and application.