Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives

Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives

Photodynamic therapy (PDT) is a minimally invasive therapeutic strategy for cancer treatment, which can destroy local tumor cells and induce systemic antitumor immune response, whereas, focusing on improving direct cytotoxicity to tumor cells treated by PDT, there is growing interest in developing a...

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Main Authors: Yamin Yang, Yue Hu, Hongjun Wang
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2016/5274084
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spelling doaj-f46f010d2c0742ac8b3dca49ab958db12020-11-24T23:19:40ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942016-01-01201610.1155/2016/52740845274084Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future PerspectivesYamin Yang0Yue Hu1Hongjun Wang2Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, 169 Sheng Tai West Road, Nanjing, Jiangsu 211106, ChinaDepartment of Biological and Environmental Engineering, Cornell University, 120 Riley Robb, Ithaca, NY 14853, USADepartment of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030, USAPhotodynamic therapy (PDT) is a minimally invasive therapeutic strategy for cancer treatment, which can destroy local tumor cells and induce systemic antitumor immune response, whereas, focusing on improving direct cytotoxicity to tumor cells treated by PDT, there is growing interest in developing approaches to further explore the immune stimulatory properties of PDT. In this review we summarize the current knowledge of the innate and adaptive immune responses induced by PDT against tumors, providing evidence showing PDT facilitated-antitumor immunity. Various immunotherapeutic approaches on different cells are reviewed for their effectiveness in improving the treatment efficiency in concert with PDT. Future perspectives are discussed for further enhancing PDT efficiency via intracellular targetable drug delivery as well as optimized experimental model development associated with the study of antitumor immune response.http://dx.doi.org/10.1155/2016/5274084
collection DOAJ
language English
format Article
sources DOAJ
author Yamin Yang
Yue Hu
Hongjun Wang
spellingShingle Yamin Yang
Yue Hu
Hongjun Wang
Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives
Oxidative Medicine and Cellular Longevity
author_facet Yamin Yang
Yue Hu
Hongjun Wang
author_sort Yamin Yang
title Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives
title_short Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives
title_full Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives
title_fullStr Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives
title_full_unstemmed Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives
title_sort targeting antitumor immune response for enhancing the efficacy of photodynamic therapy of cancer: recent advances and future perspectives
publisher Hindawi Limited
series Oxidative Medicine and Cellular Longevity
issn 1942-0900
1942-0994
publishDate 2016-01-01
description Photodynamic therapy (PDT) is a minimally invasive therapeutic strategy for cancer treatment, which can destroy local tumor cells and induce systemic antitumor immune response, whereas, focusing on improving direct cytotoxicity to tumor cells treated by PDT, there is growing interest in developing approaches to further explore the immune stimulatory properties of PDT. In this review we summarize the current knowledge of the innate and adaptive immune responses induced by PDT against tumors, providing evidence showing PDT facilitated-antitumor immunity. Various immunotherapeutic approaches on different cells are reviewed for their effectiveness in improving the treatment efficiency in concert with PDT. Future perspectives are discussed for further enhancing PDT efficiency via intracellular targetable drug delivery as well as optimized experimental model development associated with the study of antitumor immune response.
url http://dx.doi.org/10.1155/2016/5274084
work_keys_str_mv AT yaminyang targetingantitumorimmuneresponseforenhancingtheefficacyofphotodynamictherapyofcancerrecentadvancesandfutureperspectives
AT yuehu targetingantitumorimmuneresponseforenhancingtheefficacyofphotodynamictherapyofcancerrecentadvancesandfutureperspectives
AT hongjunwang targetingantitumorimmuneresponseforenhancingtheefficacyofphotodynamictherapyofcancerrecentadvancesandfutureperspectives
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