Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016)
Abstract Bilateral breast cancer (BBC) is an uncommon subset of breast cancer (BC), and it may present as synchronous bilateral breast cancer (sBBC) or metachronous bilateral breast cancer (mBBC). Through this study, we aimed to evaluate the proportion of BBC in BC and compare the clinicopathologica...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Wiley
2021-09-01
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Series: | Cancer Medicine |
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Online Access: | https://doi.org/10.1002/cam4.4141 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hanfang Jiang Ruyan Zhang Xiaoran Liu Ran Ran Jiayang Zhang Yaxin Liu Xinyu Gui Yifei Chen Kun Li Bin Shao Ying Yan Xu Liang Guohong Song Lijun Di Huiping Li |
spellingShingle |
Hanfang Jiang Ruyan Zhang Xiaoran Liu Ran Ran Jiayang Zhang Yaxin Liu Xinyu Gui Yifei Chen Kun Li Bin Shao Ying Yan Xu Liang Guohong Song Lijun Di Huiping Li Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016) Cancer Medicine bilateral breast cancer metachronous prognosis proportion synchronous |
author_facet |
Hanfang Jiang Ruyan Zhang Xiaoran Liu Ran Ran Jiayang Zhang Yaxin Liu Xinyu Gui Yifei Chen Kun Li Bin Shao Ying Yan Xu Liang Guohong Song Lijun Di Huiping Li |
author_sort |
Hanfang Jiang |
title |
Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016) |
title_short |
Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016) |
title_full |
Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016) |
title_fullStr |
Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016) |
title_full_unstemmed |
Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016) |
title_sort |
bilateral breast cancer in china: a 10‐year single‐center retrospective study (2006–2016) |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2021-09-01 |
description |
Abstract Bilateral breast cancer (BBC) is an uncommon subset of breast cancer (BC), and it may present as synchronous bilateral breast cancer (sBBC) or metachronous bilateral breast cancer (mBBC). Through this study, we aimed to evaluate the proportion of BBC in BC and compare the clinicopathological characteristics, treatment, and outcomes of sBBC and mBBC at an academic cancer center in China. Patients with BC consecutively treated between 2006 and 2016 were retrospectively reviewed. Patients with BBC were included. In total, 3924 patients with BC were analyzed and 127 patients with BBC (28 sBBC, 99 mBBC) with a median follow‐up of 98 months were identified. The proportion of BBC was 3.2% (0.7%, sBBC; 2.5%, mBBC). The median age at the first diagnosis of mBBC was significantly younger than that at the first diagnosis of sBBC (p = 0.027). Patients diagnosed as having sBBC were more likely to have a positive family history (p = 0.047). The first tumors of mBBC were detected at a significantly earlier tumor stage compared with those of sBBC (p = 0.028). The concordance rates of histopathologic type in the first and second tumors were 60.7% and 58.0% in sBBC and mBBC, respectively. sBBC had a significantly poorer disease‐free survival than mBBC did (p = 0.001). BBC is a rare disease affecting the Chinese population. sBBC is associated with a greater prevalence of a family history of breast cancer and poorer prognosis, compared with mBBC. |
topic |
bilateral breast cancer metachronous prognosis proportion synchronous |
url |
https://doi.org/10.1002/cam4.4141 |
work_keys_str_mv |
AT hanfangjiang bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT ruyanzhang bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT xiaoranliu bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT ranran bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT jiayangzhang bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT yaxinliu bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT xinyugui bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT yifeichen bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT kunli bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT binshao bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT yingyan bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT xuliang bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT guohongsong bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT lijundi bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 AT huipingli bilateralbreastcancerinchinaa10yearsinglecenterretrospectivestudy20062016 |
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doaj-f471d173616944f582224d20c66be6fb2021-09-06T09:17:13ZengWileyCancer Medicine2045-76342021-09-0110176089609810.1002/cam4.4141Bilateral breast cancer in China: A 10‐year single‐center retrospective study (2006–2016)Hanfang Jiang0Ruyan Zhang1Xiaoran Liu2Ran Ran3Jiayang Zhang4Yaxin Liu5Xinyu Gui6Yifei Chen7Kun Li8Bin Shao9Ying Yan10Xu Liang11Guohong Song12Lijun Di13Huiping Li14Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology Peking University Cancer Hospital & Institute Beijing ChinaAbstract Bilateral breast cancer (BBC) is an uncommon subset of breast cancer (BC), and it may present as synchronous bilateral breast cancer (sBBC) or metachronous bilateral breast cancer (mBBC). Through this study, we aimed to evaluate the proportion of BBC in BC and compare the clinicopathological characteristics, treatment, and outcomes of sBBC and mBBC at an academic cancer center in China. Patients with BC consecutively treated between 2006 and 2016 were retrospectively reviewed. Patients with BBC were included. In total, 3924 patients with BC were analyzed and 127 patients with BBC (28 sBBC, 99 mBBC) with a median follow‐up of 98 months were identified. The proportion of BBC was 3.2% (0.7%, sBBC; 2.5%, mBBC). The median age at the first diagnosis of mBBC was significantly younger than that at the first diagnosis of sBBC (p = 0.027). Patients diagnosed as having sBBC were more likely to have a positive family history (p = 0.047). The first tumors of mBBC were detected at a significantly earlier tumor stage compared with those of sBBC (p = 0.028). The concordance rates of histopathologic type in the first and second tumors were 60.7% and 58.0% in sBBC and mBBC, respectively. sBBC had a significantly poorer disease‐free survival than mBBC did (p = 0.001). BBC is a rare disease affecting the Chinese population. sBBC is associated with a greater prevalence of a family history of breast cancer and poorer prognosis, compared with mBBC.https://doi.org/10.1002/cam4.4141bilateral breast cancermetachronousprognosisproportionsynchronous |