YB-1 Knockdown Inhibits the Proliferation of Mesothelioma Cells through Multiple Mechanisms

YB-1 Knockdown Inhibits the Proliferation of Mesothelioma Cells through Multiple Mechanisms

Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein that has been shown to regulate proliferation, invasion and metastasis in a variety of cancer types. We previously demonstrated that YB-1 is overexpressed in mesothelioma cells and its knockdown significantly reduces tumour cell prolife...

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Bibliographic Details
Main Authors: Thomas G. Johnson, Karin Schelch, Kaitao Lai, Kamila A. Marzec, Marina Kennerson, Michael Grusch, Glen Reid, Andrew Burgess
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
Y-box protein-1
RNA-seq
cell cycle
apoptosis
G2/M checkpoint
mitosis
Online Access:https://www.mdpi.com/2072-6694/12/8/2285

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