| Summary: | It has previously shown that normal human Polymorphonuclear neutrophils (PMNs) contain cytoplasmic stores of molecules associated with cell migration. CD11b and CD18 are the most important molecules involved in cell migration. These cytoplasmic molecules were found to translocate to the cell surface with different stimuli. In this study, IL-2 in vitro activation of PMNs had acquired integrins (CD11b and CD18) on the surface. Some studies had suggested that CD11b and CD18 expressed on the surface of neutrophils might be played a role in their migration.
PMNs were originally described as short lived and terminally differentiated phagocytes that contribute only to the innate immune response. Recent evidence of PMN expression of numerous cell surface proteins has suggested that PMNs are likely to influence adaptive responses.
As our understanding of integrins as multifunctional adhesion and signaling molecules has grown, so has their recognition as potential therapeutic targets in human diseases. Leukocyte integrins are of particular interest in this regard, as they are key molecules in immune-mediated and inflammatory processes and are thus critically involved in diverse clinical disorders, ranging from asthma to atherosclerosis.
There are three types of IL-2R (?, ? and ?). In this study only IL-2Rb chain was detected on PMN using a flowcytometry examination. This gave us an impetus to define IL-2 participation in some biological properties of PMNs such as expression of CD11b and CD18.
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