FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation

An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3∙6H2O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mil...

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Main Authors:	Fei Zhao, Xiuwen Jia, Pinyi Li, Jingwei Zhao, Jun Huang, Honglian Li, Lin Li
Format:	Article
Language:	English
Published:	MDPI AG 2017-09-01
Series:	Molecules
Subjects:	FeCl3∙6H2O TMSBr dihydropyrimidinones dihydropyrimidinethiones microwave irradiation
Online Access:	https://www.mdpi.com/1420-3049/22/9/1503

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spelling	doaj-f4764db206a149b2ae375ded1b9e94bc2020-11-25T00:47:13ZengMDPI AGMolecules1420-30492017-09-01229150310.3390/molecules22091503molecules22091503FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave IrradiationFei Zhao0Xiuwen Jia1Pinyi Li2Jingwei Zhao3Jun Huang4Honglian Li5Lin Li6Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, ChinaAn efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3∙6H2O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones.https://www.mdpi.com/1420-3049/22/9/1503FeCl3∙6H2OTMSBrdihydropyrimidinonesdihydropyrimidinethionesmicrowave irradiation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fei Zhao Xiuwen Jia Pinyi Li Jingwei Zhao Jun Huang Honglian Li Lin Li
spellingShingle	Fei Zhao Xiuwen Jia Pinyi Li Jingwei Zhao Jun Huang Honglian Li Lin Li FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation Molecules FeCl3∙6H2O TMSBr dihydropyrimidinones dihydropyrimidinethiones microwave irradiation
author_facet	Fei Zhao Xiuwen Jia Pinyi Li Jingwei Zhao Jun Huang Honglian Li Lin Li
author_sort	Fei Zhao
title	FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_short	FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_full	FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_fullStr	FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_full_unstemmed	FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_sort	fecl3∙6h2o/tmsbr-catalyzed rapid synthesis of dihydropyrimidinones and dihydropyrimidinethiones under microwave irradiation
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2017-09-01
description	An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3∙6H2O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones.
topic	FeCl3∙6H2O TMSBr dihydropyrimidinones dihydropyrimidinethiones microwave irradiation
url	https://www.mdpi.com/1420-3049/22/9/1503
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FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation

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