Effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure
Objective: To explore the effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure. Methods: A total of 110 patients with chronic heart failure who were treated in the hospital between January 2015 and Janu...
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doaj-f47a4548828745989e1fc11c1612e20b2020-11-24T21:38:52ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-09-0123171720Effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failureJing Chen0Department of Cardiology, Zigong First People’s Hospital in Sichuan Province, Zigong City, Sichuan Province, 643000Objective: To explore the effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure. Methods: A total of 110 patients with chronic heart failure who were treated in the hospital between January 2015 and January 2017 were divided into control group (n=55) and observation group (n=55) by random number table method. Control group received conventional therapy for chronic heart failure, and the observation group received milrinone on the basis of conventional therapy. The differences in ultrasound cardiac function and myocardial remodeling index levels as well as serum RAAS index contents were compared between the two groups before and after treatment. Results: Before treatment, the differences in ultrasound cardiac function and myocardial remodeling index levels as well as serum RAAS index contents were not statistically significant between the two groups. After treatment, CO and SV levels of both groups of patients were significantly higher than those before treatment while LADd, LVEDd, LVPWT, IVST and LVMI levels as well as serum PRA, AngⅡ and ALD contents were significantly lower than those before treatment, and CO and SV levels of observation group were significantly higher than those of control group while LADd, LVEDd, LVPWT, IVST and LVMI levels as well as serum PRA, AngⅡ and ALD contents were significantly lower than those of control group. Conclusion: Adjuvant milrinone therapy can effectively enhance the cardiac function, inhibit the myocardial remodeling and decrease the RAAS system activity in patients with chronic heart failure.http://www.hnykdxxb.com/PDF/201717/5.pdfChronic heart failureMilrinoneCardiac functionMyocardial remodelingRAAS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Chen |
spellingShingle |
Jing Chen Effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure Journal of Hainan Medical University Chronic heart failure Milrinone Cardiac function Myocardial remodeling RAAS |
author_facet |
Jing Chen |
author_sort |
Jing Chen |
title |
Effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure |
title_short |
Effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure |
title_full |
Effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure |
title_fullStr |
Effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure |
title_full_unstemmed |
Effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and RAAS system activity in patients with chronic heart failure |
title_sort |
effect of the adjuvant milrinone therapy on cardiac function, myocardial remodeling and raas system activity in patients with chronic heart failure |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-09-01 |
description |
Objective: To explore the effect of the adjuvant milrinone therapy on cardiac function,
myocardial remodeling and RAAS system activity in patients with chronic heart failure.
Methods: A total of 110 patients with chronic heart failure who were treated in the
hospital between January 2015 and January 2017 were divided into control group (n=55)
and observation group (n=55) by random number table method. Control group received
conventional therapy for chronic heart failure, and the observation group received milrinone
on the basis of conventional therapy. The differences in ultrasound cardiac function and
myocardial remodeling index levels as well as serum RAAS index contents were compared
between the two groups before and after treatment. Results: Before treatment, the differences
in ultrasound cardiac function and myocardial remodeling index levels as well as serum RAAS
index contents were not statistically significant between the two groups. After treatment, CO
and SV levels of both groups of patients were significantly higher than those before treatment
while LADd, LVEDd, LVPWT, IVST and LVMI levels as well as serum PRA, AngⅡ and
ALD contents were significantly lower than those before treatment, and CO and SV levels of
observation group were significantly higher than those of control group while LADd, LVEDd,
LVPWT, IVST and LVMI levels as well as serum PRA, AngⅡ and ALD contents were
significantly lower than those of control group. Conclusion: Adjuvant milrinone therapy can
effectively enhance the cardiac function, inhibit the myocardial remodeling and decrease the
RAAS system activity in patients with chronic heart failure. |
topic |
Chronic heart failure Milrinone Cardiac function Myocardial remodeling RAAS |
url |
http://www.hnykdxxb.com/PDF/201717/5.pdf |
work_keys_str_mv |
AT jingchen effectoftheadjuvantmilrinonetherapyoncardiacfunctionmyocardialremodelingandraassystemactivityinpatientswithchronicheartfailure |
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1725934017455325184 |