Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach

Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach

Human immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This pro...

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Bibliographic Details
Main Authors: Paula Martins, Eduardo Castela, Graça Rocha, Cristina Sena, Raquel Seiça
Format: Article
Language:English
Published: Ordem dos Médicos 2017-10-01
Series:Acta Médica Portuguesa
Subjects:
Antirretrovirais
Aterosclerose
Criança
Factores de Risco
Infecções por HIV
Online Access:http://actamedicaportuguesa.com/revista/index.php/amp/article/view/8726
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spelling doaj-f48adc129af04dc1a231e22af66ceb5c2020-11-25T01:58:45ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582017-10-01301074274910.20344/amp.87264614Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical ApproachPaula Martins0Eduardo Castela1Graça Rocha2Cristina Sena3Raquel Seiça4Serviço de Cardiologia Pediátrica. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.Serviço de Cardiologia Pediátrica. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Pediatria Ambulatória. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Laboratório de Fisiologia. Instituto de Imagem Biomédica e Ciências da Vida (IBILI). Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.Laboratório de Fisiologia. Instituto de Imagem Biomédica e Ciências da Vida (IBILI). Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.Human immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This process is probably mediated by dyslipidaemia, dysregulation of glucose metabolism, lipodystrophy, inflammation, endothelial dysfunction and a prothrombotic state. The clinical approach to this population in terms of cardiovascular prevention is mainly based on efficient treatment of the infection, reduction of the modifiable risk factors and promotion of lifestyle changes.http://actamedicaportuguesa.com/revista/index.php/amp/article/view/8726AntirretroviraisAteroscleroseCriançaFactores de RiscoInfecções por HIV
collection DOAJ
language English
format Article
sources DOAJ
author Paula Martins
Eduardo Castela
Graça Rocha
Cristina Sena
Raquel Seiça
spellingShingle Paula Martins
Eduardo Castela
Graça Rocha
Cristina Sena
Raquel Seiça
Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
Acta Médica Portuguesa
Antirretrovirais
Aterosclerose
Criança
Factores de Risco
Infecções por HIV
author_facet Paula Martins
Eduardo Castela
Graça Rocha
Cristina Sena
Raquel Seiça
author_sort Paula Martins
title Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_short Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_full Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_fullStr Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_full_unstemmed Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach
title_sort premature atherosclerosis in hiv-infected pediatric patients: literature review and clinical approach
publisher Ordem dos Médicos
series Acta Médica Portuguesa
issn 0870-399X
1646-0758
publishDate 2017-10-01
description Human immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This process is probably mediated by dyslipidaemia, dysregulation of glucose metabolism, lipodystrophy, inflammation, endothelial dysfunction and a prothrombotic state. The clinical approach to this population in terms of cardiovascular prevention is mainly based on efficient treatment of the infection, reduction of the modifiable risk factors and promotion of lifestyle changes.
topic Antirretrovirais
Aterosclerose
Criança
Factores de Risco
Infecções por HIV
url http://actamedicaportuguesa.com/revista/index.php/amp/article/view/8726
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AT gracarocha prematureatherosclerosisinhivinfectedpediatricpatientsliteraturereviewandclinicalapproach
AT cristinasena prematureatherosclerosisinhivinfectedpediatricpatientsliteraturereviewandclinicalapproach
AT raquelseica prematureatherosclerosisinhivinfectedpediatricpatientsliteraturereviewandclinicalapproach
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