Leptin receptor polymorphism in patients with asthma and its correlation with the disease progression
Objective: To study the leptin receptor Gln223Arg locus polymorphism in patients with asthma and its correlation with the disease progression. Methods: The patients who were diagnosed with bronchial asthma in our hospital between July 2014 and April 2017 were selected as the asthma group for the...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2018-10-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201810/06.pdf |
Summary: | Objective: To study the leptin receptor Gln223Arg locus polymorphism in patients with
asthma and its correlation with the disease progression. Methods: The patients who were
diagnosed with bronchial asthma in our hospital between July 2014 and April 2017 were
selected as the asthma group for the study, and the healthy volunteers who received physical
examination in our hospital during the same period were selected as the control group. The
leptin receptor gene Gln223Arg locus polymorphism was determined, and the contents of
inflammatory mediators and airway remodeling indexes in serum as well as the contents
of immune cells in peripheral blood were determined. Results: Eotaxin, Galectin-3, YKL-
40, SAA, IL-33, ADAM33, NE and MMP9 contents in serum as well as Th17, Th9 and Tfh
contents in peripheral blood of asthma group of patients with AA+AG genotype and GG
genotype were significantly higher than those of control group whereas TIMP1 and TIMP2
contents in serum as well as Treg contents in peripheral blood were significantly lower than
those of control group; Eotaxin, Galectin-3, YKL-40, SAA, IL-33, ADAM33, NE and MMP9
contents in serum as well as Th17, Th9 and Tfh contents in peripheral blood of asthma group
of patients with AA+AG genotype were significantly higher than those of patients with GG
genotype whereas TIMP1 and TIMP2 contents in serum as well as Treg content in peripheral
blood were significantly lower than those of patients with GG genotype. Conclusion: The
substitution from leptin receptor Gln223Arg locus polymorphism A→G replacement in patients
with asthma can aggravate the inflammatory response and immune response disorder as well
as airway remodeling. |
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ISSN: | 1007-1237 1007-1237 |