Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws.

Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws.

<h4>Background</h4>Gallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, particularly DNA synthesis (due to inhibition of...

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Bibliographic Details
Main Authors: Lorenzo Giacani, Lawrence R Bernstein, Austin M Haynes, B Charmie Godornes, Giulia Ciccarese, Francesco Drago, Aurora Parodi, Sefora Valdevit, Luca Anselmi, Carlo Francesco Tomasini, Arthur M Baca
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007076

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