Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma

Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma

Background: Electrode insertion trauma (EIT) during cochlear implantation (CI) can cause loss of residual hearing. L-N-acetylcysteine (L-NAC) and dexamethasone (Dex) have been individually shown to provide otoprotection albeit at higher concentrations that may be associated with adverse effects. Obj...

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Bibliographic Details
Main Authors: Adrien A. Eshraghi, David Shahal, Camron Davies, Jeenu Mittal, Viraj Shah, Erdogan Bulut, Carolyn Garnham, Priyanka Sinha, Dibyanshi Mishra, Hannah Marwede, Rahul Mittal
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Journal of Clinical Medicine
Subjects:
electrode insertion trauma
residual hearing
l-n-acetylcysteine
dexamethasone
organ of corti
oxidative stress
proinflammatory cytokines
nitric oxide
Online Access:https://www.mdpi.com/2077-0383/9/3/716

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