Involvement of COUP-TFs in Cancer Progression
The orphan receptors COUP-TFI and COUP-TFII are members of the nuclear receptor superfamily that play distinct and critical roles in vertebrate organogenesis, as demonstrated by loss-of-function COUP-TFI and/or COUP-TFII mutant mice. Although COUP-TFs are expressed in a wide range of tissues in adul...
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2011-02-01
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doaj-f4a52af9edee4db497dc0033fd537d852020-11-25T00:56:23ZengMDPI AGCancers2072-66942011-02-013170071510.3390/cancers3010700Involvement of COUP-TFs in Cancer ProgressionFarzad PakdelFrançois Le DilyAntoine BoudotThe orphan receptors COUP-TFI and COUP-TFII are members of the nuclear receptor superfamily that play distinct and critical roles in vertebrate organogenesis, as demonstrated by loss-of-function COUP-TFI and/or COUP-TFII mutant mice. Although COUP-TFs are expressed in a wide range of tissues in adults, little is known about their functions at later stages of development or in organism homeostasis. COUP-TFs are expressed in cancer cell lines of various origins and increasing studies suggest they play roles in cell fate determination and, potentially, in cancer progression. Nevertheless, the exact roles of COUP-TFs in these processes remain unclear and even controversial. In this review, we report both in vitro and in vivo data describing known and suspected actions of COUP-TFs that suggest that these factors are involved in modification of the phenotype of cancer cells, notably of epithelial origin. http://www.mdpi.com/2072-6694/3/1/700/orphan nuclear receptorsCOUP-TFscancer progressionsteroid hormonescross-talk |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Farzad Pakdel François Le Dily Antoine Boudot |
spellingShingle |
Farzad Pakdel François Le Dily Antoine Boudot Involvement of COUP-TFs in Cancer Progression Cancers orphan nuclear receptors COUP-TFs cancer progression steroid hormones cross-talk |
author_facet |
Farzad Pakdel François Le Dily Antoine Boudot |
author_sort |
Farzad Pakdel |
title |
Involvement of COUP-TFs in Cancer Progression |
title_short |
Involvement of COUP-TFs in Cancer Progression |
title_full |
Involvement of COUP-TFs in Cancer Progression |
title_fullStr |
Involvement of COUP-TFs in Cancer Progression |
title_full_unstemmed |
Involvement of COUP-TFs in Cancer Progression |
title_sort |
involvement of coup-tfs in cancer progression |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2011-02-01 |
description |
The orphan receptors COUP-TFI and COUP-TFII are members of the nuclear receptor superfamily that play distinct and critical roles in vertebrate organogenesis, as demonstrated by loss-of-function COUP-TFI and/or COUP-TFII mutant mice. Although COUP-TFs are expressed in a wide range of tissues in adults, little is known about their functions at later stages of development or in organism homeostasis. COUP-TFs are expressed in cancer cell lines of various origins and increasing studies suggest they play roles in cell fate determination and, potentially, in cancer progression. Nevertheless, the exact roles of COUP-TFs in these processes remain unclear and even controversial. In this review, we report both in vitro and in vivo data describing known and suspected actions of COUP-TFs that suggest that these factors are involved in modification of the phenotype of cancer cells, notably of epithelial origin. |
topic |
orphan nuclear receptors COUP-TFs cancer progression steroid hormones cross-talk |
url |
http://www.mdpi.com/2072-6694/3/1/700/ |
work_keys_str_mv |
AT farzadpakdel involvementofcouptfsincancerprogression AT francoisledily involvementofcouptfsincancerprogression AT antoineboudot involvementofcouptfsincancerprogression |
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