Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome
Purpose: The aim of the current study was to evaluate the effect of melatonin administration on clinical, hormonal, inflammatory, and genetic parameters in women with polycystic ovarian syndrome (PCOS).Methods: The present randomized, double-blinded, placebo-controlled clinical trial was conducted a...
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doaj-f4ac44b86fe4412895c4685e9b0e19732020-11-24T21:50:38ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-05-011010.3389/fendo.2019.00273448898Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary SyndromeMehri Jamilian0Fatemeh Foroozanfard1Naghmeh Mirhosseini2Elham Kavossian3Esmat Aghadavod4Fereshteh Bahmani5Vahidreza Ostadmohammadi6Mersedeh Kia7Tahereh Eftekhar8Elnaz Ayati9Elnaz Ayati10Mostafa Mahdavinia11Zatollah Asemi12Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, IranGametogenesis Research Center, Kashan University of Medical Sciences, Kashan, IranSchool of Public Health, University of Saskatchewan, Saskatoon, SK, CanadaGametogenesis Research Center, Kashan University of Medical Sciences, Kashan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranDepartment of Midwifery, Gorgan Branch, Islamic Azad University, Gorgan, IranReproductive Health Research Center, Tehran University of Medical Science, Tehran, IranReproductive Health Research Center, Tehran University of Medical Science, Tehran, IranDepartment of Gynecology and Obstetrics, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranPurpose: The aim of the current study was to evaluate the effect of melatonin administration on clinical, hormonal, inflammatory, and genetic parameters in women with polycystic ovarian syndrome (PCOS).Methods: The present randomized, double-blinded, placebo-controlled clinical trial was conducted among 56 patients with PCOS, aged 18–40 years old. Subjects were randomly allocated to take either 5 mg melatonin supplements (n = 28) or placebo (n = 28) twice a day for 12 weeks.Results: Melatonin administration significantly reduced hirsutism (β −0.47; 95% CI, −0.86, −0.09; P = 0.01), serum total testosterone (β −0.11 ng/mL; 95% CI, −0.21, −0.02; P = 0.01), high-sensitivity C-reactive protein (hs-CRP) (β −0.61 mg/L; 95% CI, −0.95, −0.26; P = 0.001), and plasma malondialdehyde (MDA) levels (β −0.25 μmol/L; 95% CI, −0.38, −0.11; P < 0.001), and significantly increased plasma total antioxidant capacity (TAC) levels (β 106.07 mmol/L; 95% CI, 62.87, 149.28; P < 0.001) and total glutathione (GSH) (β 81.05 μmol/L; 95% CI, 36.08, 126.03; P = 0.001) compared with the placebo. Moreover, melatonin supplementation downregulated gene expression of interleukin-1 (IL-1) (P = 0.03) and tumor necrosis factor alpha (TNF-α) (P = 0.01) compared with the placebo.Conclusions: Overall, melatonin administration for 12 weeks to women with PCOS significantly reduced hirsutism, total testosterone, hs-CRP, and MDA, while increasing TAC and GSH levels. In addition, melatonin administration reduced gene expression of IL-1 and TNF-α.Clinical Trial Registration:www.irct.ir, identifier IRCT2017082733941N9, Available online at: https://www.irct.ir/trial/26051https://www.frontiersin.org/article/10.3389/fendo.2019.00273/fullmelatoninhormonal profilesinflammatory markerspolycystic ovary syndromeoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehri Jamilian Fatemeh Foroozanfard Naghmeh Mirhosseini Elham Kavossian Esmat Aghadavod Fereshteh Bahmani Vahidreza Ostadmohammadi Mersedeh Kia Tahereh Eftekhar Elnaz Ayati Elnaz Ayati Mostafa Mahdavinia Zatollah Asemi |
spellingShingle |
Mehri Jamilian Fatemeh Foroozanfard Naghmeh Mirhosseini Elham Kavossian Esmat Aghadavod Fereshteh Bahmani Vahidreza Ostadmohammadi Mersedeh Kia Tahereh Eftekhar Elnaz Ayati Elnaz Ayati Mostafa Mahdavinia Zatollah Asemi Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome Frontiers in Endocrinology melatonin hormonal profiles inflammatory markers polycystic ovary syndrome oxidative stress |
author_facet |
Mehri Jamilian Fatemeh Foroozanfard Naghmeh Mirhosseini Elham Kavossian Esmat Aghadavod Fereshteh Bahmani Vahidreza Ostadmohammadi Mersedeh Kia Tahereh Eftekhar Elnaz Ayati Elnaz Ayati Mostafa Mahdavinia Zatollah Asemi |
author_sort |
Mehri Jamilian |
title |
Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome |
title_short |
Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome |
title_full |
Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome |
title_fullStr |
Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome |
title_full_unstemmed |
Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome |
title_sort |
effects of melatonin supplementation on hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2019-05-01 |
description |
Purpose: The aim of the current study was to evaluate the effect of melatonin administration on clinical, hormonal, inflammatory, and genetic parameters in women with polycystic ovarian syndrome (PCOS).Methods: The present randomized, double-blinded, placebo-controlled clinical trial was conducted among 56 patients with PCOS, aged 18–40 years old. Subjects were randomly allocated to take either 5 mg melatonin supplements (n = 28) or placebo (n = 28) twice a day for 12 weeks.Results: Melatonin administration significantly reduced hirsutism (β −0.47; 95% CI, −0.86, −0.09; P = 0.01), serum total testosterone (β −0.11 ng/mL; 95% CI, −0.21, −0.02; P = 0.01), high-sensitivity C-reactive protein (hs-CRP) (β −0.61 mg/L; 95% CI, −0.95, −0.26; P = 0.001), and plasma malondialdehyde (MDA) levels (β −0.25 μmol/L; 95% CI, −0.38, −0.11; P < 0.001), and significantly increased plasma total antioxidant capacity (TAC) levels (β 106.07 mmol/L; 95% CI, 62.87, 149.28; P < 0.001) and total glutathione (GSH) (β 81.05 μmol/L; 95% CI, 36.08, 126.03; P = 0.001) compared with the placebo. Moreover, melatonin supplementation downregulated gene expression of interleukin-1 (IL-1) (P = 0.03) and tumor necrosis factor alpha (TNF-α) (P = 0.01) compared with the placebo.Conclusions: Overall, melatonin administration for 12 weeks to women with PCOS significantly reduced hirsutism, total testosterone, hs-CRP, and MDA, while increasing TAC and GSH levels. In addition, melatonin administration reduced gene expression of IL-1 and TNF-α.Clinical Trial Registration:www.irct.ir, identifier IRCT2017082733941N9, Available online at: https://www.irct.ir/trial/26051 |
topic |
melatonin hormonal profiles inflammatory markers polycystic ovary syndrome oxidative stress |
url |
https://www.frontiersin.org/article/10.3389/fendo.2019.00273/full |
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