Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan
Abstract Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real‐world sa...
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Language: | English |
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2021-06-01
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Series: | Cancer Medicine |
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Online Access: | https://doi.org/10.1002/cam4.3927 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chikatoshi Katada Manabu Muto Satoshi Fujii Tetsuji Yokoyama Tomonori Yano Akihito Watanabe Toshiro Iizuka Shigetaka Yoshinaga Ichiro Tateya Hiroki Mitani Yuichi Shimizu Akiko Takahashi Tomoyuki Kamijo Noboru Hanaoka Makoto Abe Akihiro Shiotani Koichi Kano Yukinori Asada Tamotsu Matsuhashi Hirohito Umeno Kenji Okami Kenichi Goda Shinichiro Hori Yoichiro Ono Shuji Terai Yasuaki Nagami Kenichi Takemura Kenro Kawada Mizuo Ando Naoto Shimeno Akihito Arai Yasutoshi Sakamoto Masaaki Ichinoe Tetsuo Nemoto Masahiro Fujita Hidenobu Watanabe Tadakazu Shimoda Atsushi Ochiai Takakuni Kato Ryuichi Hayashi |
spellingShingle |
Chikatoshi Katada Manabu Muto Satoshi Fujii Tetsuji Yokoyama Tomonori Yano Akihito Watanabe Toshiro Iizuka Shigetaka Yoshinaga Ichiro Tateya Hiroki Mitani Yuichi Shimizu Akiko Takahashi Tomoyuki Kamijo Noboru Hanaoka Makoto Abe Akihiro Shiotani Koichi Kano Yukinori Asada Tamotsu Matsuhashi Hirohito Umeno Kenji Okami Kenichi Goda Shinichiro Hori Yoichiro Ono Shuji Terai Yasuaki Nagami Kenichi Takemura Kenro Kawada Mizuo Ando Naoto Shimeno Akihito Arai Yasutoshi Sakamoto Masaaki Ichinoe Tetsuo Nemoto Masahiro Fujita Hidenobu Watanabe Tadakazu Shimoda Atsushi Ochiai Takakuni Kato Ryuichi Hayashi Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan Cancer Medicine head and neck cancer larynx preservation pharyngeal cancer superficial cancer transoral surgery |
author_facet |
Chikatoshi Katada Manabu Muto Satoshi Fujii Tetsuji Yokoyama Tomonori Yano Akihito Watanabe Toshiro Iizuka Shigetaka Yoshinaga Ichiro Tateya Hiroki Mitani Yuichi Shimizu Akiko Takahashi Tomoyuki Kamijo Noboru Hanaoka Makoto Abe Akihiro Shiotani Koichi Kano Yukinori Asada Tamotsu Matsuhashi Hirohito Umeno Kenji Okami Kenichi Goda Shinichiro Hori Yoichiro Ono Shuji Terai Yasuaki Nagami Kenichi Takemura Kenro Kawada Mizuo Ando Naoto Shimeno Akihito Arai Yasutoshi Sakamoto Masaaki Ichinoe Tetsuo Nemoto Masahiro Fujita Hidenobu Watanabe Tadakazu Shimoda Atsushi Ochiai Takakuni Kato Ryuichi Hayashi |
author_sort |
Chikatoshi Katada |
title |
Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan |
title_short |
Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan |
title_full |
Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan |
title_fullStr |
Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan |
title_full_unstemmed |
Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan |
title_sort |
transoral surgery for superficial head and neck cancer: national multi‐center survey in japan |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2021-06-01 |
description |
Abstract Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real‐world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1–75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2–357). Adverse events occurred in 12.7%. Life‐threatening complications occurred in 0.5%, but there were no treatment‐related deaths. During a median follow‐up period of 46.1 months (range 1–113), the 3‐year overall survival rate, relapse‐free survival rate, cause‐specific survival rate, and larynx‐preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment. Clinical trials registry number: UMIN000008276. |
topic |
head and neck cancer larynx preservation pharyngeal cancer superficial cancer transoral surgery |
url |
https://doi.org/10.1002/cam4.3927 |
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doaj-f4af6829c8b942789bb8b6f4e8065e2a2021-06-17T09:30:44ZengWileyCancer Medicine2045-76342021-06-0110123848386110.1002/cam4.3927Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in JapanChikatoshi Katada0Manabu Muto1Satoshi Fujii2Tetsuji Yokoyama3Tomonori Yano4Akihito Watanabe5Toshiro Iizuka6Shigetaka Yoshinaga7Ichiro Tateya8Hiroki Mitani9Yuichi Shimizu10Akiko Takahashi11Tomoyuki Kamijo12Noboru Hanaoka13Makoto Abe14Akihiro Shiotani15Koichi Kano16Yukinori Asada17Tamotsu Matsuhashi18Hirohito Umeno19Kenji Okami20Kenichi Goda21Shinichiro Hori22Yoichiro Ono23Shuji Terai24Yasuaki Nagami25Kenichi Takemura26Kenro Kawada27Mizuo Ando28Naoto Shimeno29Akihito Arai30Yasutoshi Sakamoto31Masaaki Ichinoe32Tetsuo Nemoto33Masahiro Fujita34Hidenobu Watanabe35Tadakazu Shimoda36Atsushi Ochiai37Takakuni Kato38Ryuichi Hayashi39Department of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Therapeutic Oncology Kyoto University Graduate School of Medicine Kyoto JapanDepartment of Molecular Pathology Yokohama City University School of Medicine Yokohama JapanDepartment of Health Promotion National Institute of Public Health Wako JapanDepartment of Gastroenterology and Endoscopy National Cancer Center Hospital East Kashiwa JapanDepartment of Otolaryngology Keiyukai Sapporo Hospital Sapporo JapanDepartment of Gastroenterology Toranomon Hospital Tokyo JapanEndoscopy Division National Cancer Center Hospital Tokyo JapanDepartment of Otolaryngology ‐ Head and Neck Surgery Kyoto University Kyoto JapanDepartment of Head and Neck Oncology Cancer Institute Hospital Tokyo JapanDivision of Endoscopy Hokkaido University Hospital Sapporo JapanDepartment of Endoscopy Saku Central Hospital Advanced Care Center Saku JapanDivision of Head and Neck Surgery Shizuoka Cancer Center Nagaizumi JapanDepartment of Gastrointestinal Oncology Osaka International Cancer Institute Osaka JapanDepartment of Gastroenterology and Hepatology Okayama University Graduate School Okayama JapanDepartment of Otolaryngology‐Head and Neck Surgery National Defense Medical College Tokorozawa JapanDepartment of Otorhinolaryngology ‐ Head and Neck Surgery Kitasato University School of Medicine Sagamihara JapanDepartment of Head and Neck Surgery Miyagi Cancer Center Natori JapanDepartment of Gastroenterology Akita University School of Medicine Akita JapanDepartment of Otolaryngology‐ Head and Neck Surgery Kurume University School of Medicine Kurume JapanDepartment of Otolaryngology‐ Head and Neck Surgery Tokai University Isehara JapanDepartment of Endoscopy The Jikei University School of Medicine Tokyo JapanDepartment of Endoscopy NHO Shikoku Cancer Center Matsuyama JapanDepartment of Gastroenterology Fukuoka University Chikushi Hospital Chikushino JapanDivision of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University Niigata JapanDepartment of Gastroenterology Osaka City University Graduate School of Medicine Osaka JapanDepartment of Gastroenterology Ishikawa Prefectural Central Hospital Kanazawa JapanDepartment of Gastrointestinal Surgery Tokyo Medical and Dental University Tokyo JapanDepartment of Otolaryngology ‐ Head and Neck Surgery Graduate School of Medicine University of Tokyo Tokyo JapanDepartment of Gastroenterology Kobe City Medical Center General Hospital Kobe JapanDepartment of Otolaryngology‐Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto JapanKitasato Clinical Research Center Kitasato University School of Medicine Sagamihara JapanDepartment of Pathology Kitasato University School of Medicine Sagamihara JapanDepartment of Diagnostic Pathology Showa University School of MedicineYokohama Northern Hospital Yokohama JapanDepartment of Clinical Pathology Sapporo Hokuyu Hospital Sapporo JapanDepartment of Pathology Pathology and Cytology Laboratories BML INC Tokyo JapanDepartment of Diagnostic Pathology Shizuoka Cancer Center Nagaizumi JapanExploratory Oncology Research and Clinical Trial Center National Cancer Center Kashiwa JapanDepartment of Otorhinolaryngology ‐ Head and Neck Surgery The Jikei University School of Medicine Tokyo JapanDepartment of Head and Neck Surgery National Cancer Center Hospital East Kashiwa JapanAbstract Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real‐world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1–75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2–357). Adverse events occurred in 12.7%. Life‐threatening complications occurred in 0.5%, but there were no treatment‐related deaths. During a median follow‐up period of 46.1 months (range 1–113), the 3‐year overall survival rate, relapse‐free survival rate, cause‐specific survival rate, and larynx‐preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment. Clinical trials registry number: UMIN000008276.https://doi.org/10.1002/cam4.3927head and neck cancerlarynx preservationpharyngeal cancersuperficial cancertransoral surgery |