Impact of Lactate Clearance on Early Outcomes in Pediatric ECMO Patients

• Main Authors: Julia Merkle-Storms, Ilija Djordjevic, Carolyn Weber, Soi Avgeridou, Ihor Krasivskyi, Christopher Gaisendrees, Navid Mader, Ferdinand Kuhn-Régnier, Axel Kröner, Gerardus Bennink, Anton Sabashnikov, Uwe Trieschmann, Thorsten Wahlers, Christoph Menzel
• Format: Article
• Language: English
• Published: MDPI AG 2021-03-01
• Series: Medicina
• Subjects: lactate; lactate clearance; ECMO; pediatric ECMO patients; early outcomes; survival
• Online Access: https://www.mdpi.com/1648-9144/57/3/284
• ISSN: 1010-660X; 1648-9144

<i>Background and Objectives:</i> Pediatric extracorporeal membrane oxygenation (ECMO) support is often the ultimate therapy for neonatal and pediatric patients with congenital heart defects after cardiac surgery. The impact of lactate clearance in pediatric patients during ECMO therapy on outcomes has been analyzed. Materials <i>and</i><i>Methods:</i> We retrospectively analyzed data from 41 pediatric vaECMO patients between January 2006 and December 2016. Blood lactate and lactate clearance have been recorded prior to ECMO implantation and 3, 6, 9 and 12 h after ECMO start. Receiver operating characteristic (ROC) analysis was used to identify cut-off levels for lactate clearance. <i>Results:</i> Lactate levels prior to ECMO therapy (9.8 mmol/L vs. 13.5 mmol/L; <i>p</i> = 0.07) and peak lactate levels during ECMO support (10.4 mmol/L vs. 14.7 mmol/L; <i>p</i> = 0.07) were similar between survivors and nonsurvivors. Areas under the curve (AUC) of lactate clearance at 3, 9 h and 12 h after ECMO start were significantly predictive for mortality (<i>p</i> = 0.017, <i>p</i> = 0.049 and <i>p</i> = 0.006, respectively). Cut-off values of lactate clearance were 3.8%, 51% and 56%. Duration of ECMO support and respiratory ventilation was significantly longer in survivors than in nonsurvivors (<i>p</i> = 0.01 and <i>p</i> < 0.001, respectively). <i>Conclusions:</i> Dynamic recording of lactate clearance after ECMO start is a valuable tool to assess outcomes and effectiveness of ECMO application. Poor lactate clearance during ECMO therapy in pediatric patients is a significant marker for higher mortality.