Emerging important roles of circRNAs in human cancer and other diseases
CircRNAs are a large class of endogenous single-stranded RNA that is different from other linear RNA, which are produced by back-splicing and fusion of either exons, introns, or both exon-intron into covalently closed loops. CircRNAs are found in almost all living organisms and have emerged as poten...
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doaj-f4bea6a241f54c4588f6f9eb613e38ad2021-06-11T05:14:51ZengElsevierGenes and Diseases2352-30422021-07-0184412423Emerging important roles of circRNAs in human cancer and other diseasesYong Huang0Cai Zhang1Jianli Xiong2Hongtao Ren3Corresponding author.; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan Province, 471023, PR ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan Province, 471023, PR ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan Province, 471023, PR ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan Province, 471023, PR ChinaCircRNAs are a large class of endogenous single-stranded RNA that is different from other linear RNA, which are produced by back-splicing and fusion of either exons, introns, or both exon-intron into covalently closed loops. CircRNAs are found in almost all living organisms and have emerged as potentially important players effecting on all life activities. It was characterized by stable structure, resistant to RNA degradation, highly abundance and conservation and tissue-specific expression. Early circRNAs were ignored as a by-product of meaningless abnormally cut RNA and had little biological function. Currently, circRNAs have become a research hotspot due to its special characteristics. CircRNAs could function as miRNA sponges, interfere with splicing and bind to protein to regulate the expression of parental genes and so on. In recent years, an increasing number of studies have revealed that circRNAs are closely related to a series of physiological and pathological processes. Additionally, circRNAs play an important role in the occurrence and development of a variety of diseases, suggesting circRNAs may be as novel indicators or biomarkers for cancer and other diseases with which they are associated. In this article, we review the biogenesis, biological functions of circRNAs and recent advances in circRNAs research in human diseases. Results will provide new insights on the roles and new ideas of circRNAs for the diagnosis and treatment of diseases and possible directions and approach for future circRNA applications.http://www.sciencedirect.com/science/article/pii/S2352304220300957BiogenesisCancerCircRNAsDiseasesFunctionRegulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Huang Cai Zhang Jianli Xiong Hongtao Ren |
spellingShingle |
Yong Huang Cai Zhang Jianli Xiong Hongtao Ren Emerging important roles of circRNAs in human cancer and other diseases Genes and Diseases Biogenesis Cancer CircRNAs Diseases Function Regulation |
author_facet |
Yong Huang Cai Zhang Jianli Xiong Hongtao Ren |
author_sort |
Yong Huang |
title |
Emerging important roles of circRNAs in human cancer and other diseases |
title_short |
Emerging important roles of circRNAs in human cancer and other diseases |
title_full |
Emerging important roles of circRNAs in human cancer and other diseases |
title_fullStr |
Emerging important roles of circRNAs in human cancer and other diseases |
title_full_unstemmed |
Emerging important roles of circRNAs in human cancer and other diseases |
title_sort |
emerging important roles of circrnas in human cancer and other diseases |
publisher |
Elsevier |
series |
Genes and Diseases |
issn |
2352-3042 |
publishDate |
2021-07-01 |
description |
CircRNAs are a large class of endogenous single-stranded RNA that is different from other linear RNA, which are produced by back-splicing and fusion of either exons, introns, or both exon-intron into covalently closed loops. CircRNAs are found in almost all living organisms and have emerged as potentially important players effecting on all life activities. It was characterized by stable structure, resistant to RNA degradation, highly abundance and conservation and tissue-specific expression. Early circRNAs were ignored as a by-product of meaningless abnormally cut RNA and had little biological function. Currently, circRNAs have become a research hotspot due to its special characteristics. CircRNAs could function as miRNA sponges, interfere with splicing and bind to protein to regulate the expression of parental genes and so on. In recent years, an increasing number of studies have revealed that circRNAs are closely related to a series of physiological and pathological processes. Additionally, circRNAs play an important role in the occurrence and development of a variety of diseases, suggesting circRNAs may be as novel indicators or biomarkers for cancer and other diseases with which they are associated. In this article, we review the biogenesis, biological functions of circRNAs and recent advances in circRNAs research in human diseases. Results will provide new insights on the roles and new ideas of circRNAs for the diagnosis and treatment of diseases and possible directions and approach for future circRNA applications. |
topic |
Biogenesis Cancer CircRNAs Diseases Function Regulation |
url |
http://www.sciencedirect.com/science/article/pii/S2352304220300957 |
work_keys_str_mv |
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