Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran

Toxoplasmosis is a neglected parasitic disease with global distribution in warm-blooded vertebrates and high prevalence among different human societies. We contrived a systematic review and meta-analysis on the prevalence of toxoplasmosis in Iran. Following the general methodology recommended for sy...

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Main Authors: Masoud Foroutan, Sahar Dalvand, Ahmad Daryani, Ehsan Ahmadpour, Hamidreza Majidiani, Shahram Khademvatan, Esmaeil Abbasi
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Alexandria Journal of Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S209050681730088X
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spelling doaj-f4c63d419c884fb0a09039206d6f651d2021-01-02T06:54:37ZengTaylor & Francis GroupAlexandria Journal of Medicine2090-50682018-09-01543189196Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in IranMasoud Foroutan0Sahar Dalvand1Ahmad Daryani2Ehsan Ahmadpour3Hamidreza Majidiani4Shahram Khademvatan5Esmaeil Abbasi6Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Student Research Committee, Urmia University of Medical Sciences, Urmia, IranClinical Care Research Center, Kurdistan University of Medical Sciences, Sanandaj, IranToxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, IranInfectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran; Corresponding authors.Cellular and Molecular Research Center & Department of Medical Parasitology and Mycology, Urmia University of Medical Sciences, Urmia, Iran; Corresponding authors.Student Research Committee, Urmia University of Medical Sciences, Urmia, IranToxoplasmosis is a neglected parasitic disease with global distribution in warm-blooded vertebrates and high prevalence among different human societies. We contrived a systematic review and meta-analysis on the prevalence of toxoplasmosis in Iran. Following the general methodology recommended for systematic reviews and meta-analysis, four English and three Persian electronic databases were explored up to April 2016. Out of 105,139 examined samples of different hosts, the weighted overall prevalence was 37% (95% CI = 31–43). Due to the significant heterogeneity (I2 = 81.9%) the random-effects model was used. The pool estimated prevalence of toxoplasmosis in human intermediate hosts, animal intermediate hosts, and definitive hosts was 43% (95% CI = 38–47), 26 (95% CI = 17–35) and, 34% (95% CI = 22–46), respectively. Our results represent that regular inspection in food industries, improved screening programs using standard diagnostic assay as well as distinguishing toxoplasmosis condition in other zoonotic hosts are extremely recommended for better disease management in Iran. Keywords: Toxoplasma gondii, Prevalence, Iran, Systematic review, Meta-analysishttp://www.sciencedirect.com/science/article/pii/S209050681730088X
collection DOAJ
language English
format Article
sources DOAJ
author Masoud Foroutan
Sahar Dalvand
Ahmad Daryani
Ehsan Ahmadpour
Hamidreza Majidiani
Shahram Khademvatan
Esmaeil Abbasi
spellingShingle Masoud Foroutan
Sahar Dalvand
Ahmad Daryani
Ehsan Ahmadpour
Hamidreza Majidiani
Shahram Khademvatan
Esmaeil Abbasi
Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran
Alexandria Journal of Medicine
author_facet Masoud Foroutan
Sahar Dalvand
Ahmad Daryani
Ehsan Ahmadpour
Hamidreza Majidiani
Shahram Khademvatan
Esmaeil Abbasi
author_sort Masoud Foroutan
title Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran
title_short Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran
title_full Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran
title_fullStr Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran
title_full_unstemmed Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran
title_sort rolling up the pieces of a puzzle: a systematic review and meta-analysis of the prevalence of toxoplasmosis in iran
publisher Taylor & Francis Group
series Alexandria Journal of Medicine
issn 2090-5068
publishDate 2018-09-01
description Toxoplasmosis is a neglected parasitic disease with global distribution in warm-blooded vertebrates and high prevalence among different human societies. We contrived a systematic review and meta-analysis on the prevalence of toxoplasmosis in Iran. Following the general methodology recommended for systematic reviews and meta-analysis, four English and three Persian electronic databases were explored up to April 2016. Out of 105,139 examined samples of different hosts, the weighted overall prevalence was 37% (95% CI = 31–43). Due to the significant heterogeneity (I2 = 81.9%) the random-effects model was used. The pool estimated prevalence of toxoplasmosis in human intermediate hosts, animal intermediate hosts, and definitive hosts was 43% (95% CI = 38–47), 26 (95% CI = 17–35) and, 34% (95% CI = 22–46), respectively. Our results represent that regular inspection in food industries, improved screening programs using standard diagnostic assay as well as distinguishing toxoplasmosis condition in other zoonotic hosts are extremely recommended for better disease management in Iran. Keywords: Toxoplasma gondii, Prevalence, Iran, Systematic review, Meta-analysis
url http://www.sciencedirect.com/science/article/pii/S209050681730088X
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