Study of Urinary Alpha Glutathione-S-Transferase (Alpha GST) in Children with Idiopathic Nephrotic Syndrome
Background: Glomerulopathy associated with recurrent or persistent proteinuria may lead to progressive tubulointerstitial fibrosis. Early detec-tion of tubulointerstitial fibrosis may result in a more favorable outcome of chronic kidney disease (CKD) because nephroprotective treatment may be instit...
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doaj-f4c7e90474754a50a01af6c9d91686c72021-05-23T20:29:15ZengCodon PublicationsJournal of Renal and Hepatic Disorders2207-37442020-08-014210.15586/jrenhep.v4i3.78Study of Urinary Alpha Glutathione-S-Transferase (Alpha GST) in Children with Idiopathic Nephrotic SyndromeManal Abdel-Salam0Houriah Ahmed Allam1Shams Kholoussi2Asmaa Abd El-Wakeel Ibrahim3Shaimaa Adel Abd El-Hakeim4Al-Azhar University, Cairo, EgyptAl-Azhar University, Cairo, EgyptNational Research Institute, Cairo, EgyptAl-Azhar University, Cairo, EgyptAl-Azhar University, Cairo, Egypt Background: Glomerulopathy associated with recurrent or persistent proteinuria may lead to progressive tubulointerstitial fibrosis. Early detec-tion of tubulointerstitial fibrosis may result in a more favorable outcome of chronic kidney disease (CKD) because nephroprotective treatment may be instituted in due course. One of the early markers of tubulointerstitial fibrosis is glutathione S-transferase (GST). The aim: The aim of this study was to determine urinary alpha-GST in children with idiopathic nephrotic syndrome (INS), either in remission or relapse. Material and methods: This case–control study included 40 children with primary nephrotic syndrome (NS), either in remission or relapse. Also, 40 healthy children, age- and sex-matched as controls, were selected from the outpatients and the pediatric nephrology unit of Al-Zahraa Hos-pital, Al-Azhar University. Urinary alpha-GST was investigated in the study groups on the same lines as that of routine investigations of INS. Results: Children with INS have significantly higher urinary GST either in remission or relapse, it was (5.23 ± 1.90) ng/mL, (5.32 ± 1.52) ng/mL respectively compared with healthy controls, it was (2.59 ± 1.12) ng/mL with (P = 0.001). A positive correlation between urinary alpha-GST and body weight BW, height, body mass index (BMI), white blood cells (WBCs) count, erythrocyte sedimentation rate, serum (cholesterol, triglycer-ide [TG]) level, blood urea nitrogen (BUN), and duration of the disease. Conclusion: Urinary alpha-GST was increased in children with NS even after remission, and it consequently led to oxidative stress and tubuloint-erstitial fibrosis. Nephroprotective treatment is recommended even in cases with INS, either in remission or relapse. https://jrenhep.com/index.php/jrenhep/article/view/78: Nephrotic Syndrome, Urinary Alpha GST, Children |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manal Abdel-Salam Houriah Ahmed Allam Shams Kholoussi Asmaa Abd El-Wakeel Ibrahim Shaimaa Adel Abd El-Hakeim |
spellingShingle |
Manal Abdel-Salam Houriah Ahmed Allam Shams Kholoussi Asmaa Abd El-Wakeel Ibrahim Shaimaa Adel Abd El-Hakeim Study of Urinary Alpha Glutathione-S-Transferase (Alpha GST) in Children with Idiopathic Nephrotic Syndrome Journal of Renal and Hepatic Disorders : Nephrotic Syndrome, Urinary Alpha GST, Children |
author_facet |
Manal Abdel-Salam Houriah Ahmed Allam Shams Kholoussi Asmaa Abd El-Wakeel Ibrahim Shaimaa Adel Abd El-Hakeim |
author_sort |
Manal Abdel-Salam |
title |
Study of Urinary Alpha Glutathione-S-Transferase (Alpha GST) in Children with Idiopathic Nephrotic Syndrome |
title_short |
Study of Urinary Alpha Glutathione-S-Transferase (Alpha GST) in Children with Idiopathic Nephrotic Syndrome |
title_full |
Study of Urinary Alpha Glutathione-S-Transferase (Alpha GST) in Children with Idiopathic Nephrotic Syndrome |
title_fullStr |
Study of Urinary Alpha Glutathione-S-Transferase (Alpha GST) in Children with Idiopathic Nephrotic Syndrome |
title_full_unstemmed |
Study of Urinary Alpha Glutathione-S-Transferase (Alpha GST) in Children with Idiopathic Nephrotic Syndrome |
title_sort |
study of urinary alpha glutathione-s-transferase (alpha gst) in children with idiopathic nephrotic syndrome |
publisher |
Codon Publications |
series |
Journal of Renal and Hepatic Disorders |
issn |
2207-3744 |
publishDate |
2020-08-01 |
description |
Background: Glomerulopathy associated with recurrent or persistent proteinuria may lead to progressive tubulointerstitial fibrosis. Early detec-tion of tubulointerstitial fibrosis may result in a more favorable outcome of chronic kidney disease (CKD) because nephroprotective treatment may be instituted in due course. One of the early markers of tubulointerstitial fibrosis is glutathione S-transferase (GST).
The aim: The aim of this study was to determine urinary alpha-GST in children with idiopathic nephrotic syndrome (INS), either in remission or relapse.
Material and methods: This case–control study included 40 children with primary nephrotic syndrome (NS), either in remission or relapse. Also, 40 healthy children, age- and sex-matched as controls, were selected from the outpatients and the pediatric nephrology unit of Al-Zahraa Hos-pital, Al-Azhar University. Urinary alpha-GST was investigated in the study groups on the same lines as that of routine investigations of INS.
Results: Children with INS have significantly higher urinary GST either in remission or relapse, it was (5.23 ± 1.90) ng/mL, (5.32 ± 1.52) ng/mL respectively compared with healthy controls, it was (2.59 ± 1.12) ng/mL with (P = 0.001). A positive correlation between urinary alpha-GST and body weight BW, height, body mass index (BMI), white blood cells (WBCs) count, erythrocyte sedimentation rate, serum (cholesterol, triglycer-ide [TG]) level, blood urea nitrogen (BUN), and duration of the disease.
Conclusion: Urinary alpha-GST was increased in children with NS even after remission, and it consequently led to oxidative stress and tubuloint-erstitial fibrosis. Nephroprotective treatment is recommended even in cases with INS, either in remission or relapse.
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topic |
: Nephrotic Syndrome, Urinary Alpha GST, Children |
url |
https://jrenhep.com/index.php/jrenhep/article/view/78 |
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