Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review
Magnetic nanoparticles (MNPs) have great potential in biomedical and clinical applications because of their many unique properties. This contribution provides an overview of the MNPs mainly used in the field of amyloid diseases. The first part discusses their use in understanding the amyloid mechani...
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doaj-f4cdf16566c84994bd82ed4ec5ee4f5e2020-11-24T21:27:50ZengMDPI AGNanomaterials2079-49912018-09-018974010.3390/nano8090740nano8090740Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A ReviewJonathan Pansieri0Matthieu Gerstenmayer1François Lux2Sebastien Mériaux3Olivier Tillement4Vincent Forge5Benoit Larrat6Christel Marquette7Laboratoire de Chimie et Biologie des Métaux, Université Grenoble Alpes, CNRS, CEA, 17 Rue des Martyrs, CEDEX 9, 38041 Grenoble, FranceNeuroSpin, CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette CEDEX, FranceInstitut Lumière Matière, Université Claude Bernard Lyon 1, 69621 Villeurbanne CEDEX, FranceNeuroSpin, CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette CEDEX, FranceInstitut Lumière Matière, Université Claude Bernard Lyon 1, 69621 Villeurbanne CEDEX, FranceLaboratoire de Chimie et Biologie des Métaux, Université Grenoble Alpes, CNRS, CEA, 17 Rue des Martyrs, CEDEX 9, 38041 Grenoble, FranceNeuroSpin, CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette CEDEX, FranceLaboratoire de Chimie et Biologie des Métaux, Université Grenoble Alpes, CNRS, CEA, 17 Rue des Martyrs, CEDEX 9, 38041 Grenoble, FranceMagnetic nanoparticles (MNPs) have great potential in biomedical and clinical applications because of their many unique properties. This contribution provides an overview of the MNPs mainly used in the field of amyloid diseases. The first part discusses their use in understanding the amyloid mechanisms of fibrillation, with emphasis on their ability to control aggregation of amyloidogenic proteins. The second part deals with the functionalization by various moieties of numerous MNPs’ surfaces (molecules, peptides, antibody fragments, or whole antibodies of MNPs) for the detection and the quantification of amyloid aggregates. The last part of this review focuses on the use of MNPs for magnetic-resonance-based amyloid imaging in biomedical fields, with particular attention to the application of gadolinium-based paramagnetic nanoparticles (AGuIX), which have been recently developed. Biocompatible AGuIX nanoparticles show favorable characteristics for in vivo use, such as nanometric and straightforward functionalization. Their properties have enabled their application in MRI. Here, we report that AGuIX nanoparticles grafted with the Pittsburgh compound B can actively target amyloid aggregates in the brain, beyond the blood–brain barrier, and remain the first step in observing amyloid plaques in a mouse model of Alzheimer’s disease.http://www.mdpi.com/2079-4991/8/9/740magnetic nanoparticlesamyloidosisAlzheimer’s diseasestargeted nanoparticlesmedical imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonathan Pansieri Matthieu Gerstenmayer François Lux Sebastien Mériaux Olivier Tillement Vincent Forge Benoit Larrat Christel Marquette |
spellingShingle |
Jonathan Pansieri Matthieu Gerstenmayer François Lux Sebastien Mériaux Olivier Tillement Vincent Forge Benoit Larrat Christel Marquette Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review Nanomaterials magnetic nanoparticles amyloidosis Alzheimer’s diseases targeted nanoparticles medical imaging |
author_facet |
Jonathan Pansieri Matthieu Gerstenmayer François Lux Sebastien Mériaux Olivier Tillement Vincent Forge Benoit Larrat Christel Marquette |
author_sort |
Jonathan Pansieri |
title |
Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review |
title_short |
Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review |
title_full |
Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review |
title_fullStr |
Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review |
title_full_unstemmed |
Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review |
title_sort |
magnetic nanoparticles applications for amyloidosis study and detection: a review |
publisher |
MDPI AG |
series |
Nanomaterials |
issn |
2079-4991 |
publishDate |
2018-09-01 |
description |
Magnetic nanoparticles (MNPs) have great potential in biomedical and clinical applications because of their many unique properties. This contribution provides an overview of the MNPs mainly used in the field of amyloid diseases. The first part discusses their use in understanding the amyloid mechanisms of fibrillation, with emphasis on their ability to control aggregation of amyloidogenic proteins. The second part deals with the functionalization by various moieties of numerous MNPs’ surfaces (molecules, peptides, antibody fragments, or whole antibodies of MNPs) for the detection and the quantification of amyloid aggregates. The last part of this review focuses on the use of MNPs for magnetic-resonance-based amyloid imaging in biomedical fields, with particular attention to the application of gadolinium-based paramagnetic nanoparticles (AGuIX), which have been recently developed. Biocompatible AGuIX nanoparticles show favorable characteristics for in vivo use, such as nanometric and straightforward functionalization. Their properties have enabled their application in MRI. Here, we report that AGuIX nanoparticles grafted with the Pittsburgh compound B can actively target amyloid aggregates in the brain, beyond the blood–brain barrier, and remain the first step in observing amyloid plaques in a mouse model of Alzheimer’s disease. |
topic |
magnetic nanoparticles amyloidosis Alzheimer’s diseases targeted nanoparticles medical imaging |
url |
http://www.mdpi.com/2079-4991/8/9/740 |
work_keys_str_mv |
AT jonathanpansieri magneticnanoparticlesapplicationsforamyloidosisstudyanddetectionareview AT matthieugerstenmayer magneticnanoparticlesapplicationsforamyloidosisstudyanddetectionareview AT francoislux magneticnanoparticlesapplicationsforamyloidosisstudyanddetectionareview AT sebastienmeriaux magneticnanoparticlesapplicationsforamyloidosisstudyanddetectionareview AT oliviertillement magneticnanoparticlesapplicationsforamyloidosisstudyanddetectionareview AT vincentforge magneticnanoparticlesapplicationsforamyloidosisstudyanddetectionareview AT benoitlarrat magneticnanoparticlesapplicationsforamyloidosisstudyanddetectionareview AT christelmarquette magneticnanoparticlesapplicationsforamyloidosisstudyanddetectionareview |
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