Benefit–Risk Assessment of the French Surveillance Protocol of Apparently Healthy Biting Dogs and Cats for Human Rabies Prevention
In France, apparently healthy dogs and cats that bite humans must undergo an observation period of 15 days with three veterinary visits to ascertain that they remain healthy, indicating that no zoonotic transmission of rabies virus occurred via salivary presymptomatic excretion. This surveillance pr...
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doaj-f4d44b689fc3403494741258e781fa372021-07-23T14:10:59ZengMDPI AGVeterinary Sciences2306-73812021-07-01813213210.3390/vetsci8070132Benefit–Risk Assessment of the French Surveillance Protocol of Apparently Healthy Biting Dogs and Cats for Human Rabies PreventionGuillaume Crozet0Tiffany Charmet1Florence Cliquet2Emmanuelle Robardet3Barbara Dufour4Julie Rivière5Laboratoire de Santé Animale USC EPIMAI, Anses, Ecole Nationale Vétérinaire d’Alfort, F-94700 Maisons-Alfort, FranceLaboratoire de Santé Animale USC EPIMAI, Anses, Ecole Nationale Vétérinaire d’Alfort, F-94700 Maisons-Alfort, FranceNancy Laboratory for Rabies and Wildlife, Anses, F-54220 Malzéville, FranceNancy Laboratory for Rabies and Wildlife, Anses, F-54220 Malzéville, FranceLaboratoire de Santé Animale USC EPIMAI, Anses, Ecole Nationale Vétérinaire d’Alfort, F-94700 Maisons-Alfort, FranceLaboratoire de Santé Animale USC EPIMAI, Anses, Ecole Nationale Vétérinaire d’Alfort, F-94700 Maisons-Alfort, FranceIn France, apparently healthy dogs and cats that bite humans must undergo an observation period of 15 days with three veterinary visits to ascertain that they remain healthy, indicating that no zoonotic transmission of rabies virus occurred via salivary presymptomatic excretion. This surveillance protocol is mandatory for all pets that have bitten humans, despite France’s rabies-free status in non-flying mammals (i.e., a very low rabies risk). In this context, we aimed to perform a benefit–risk assessment of the existing regulatory surveillance protocol of apparently healthy biting animals, as well as alternative surveillance protocols. A scenario-tree modelling approach was used to consider the possible successions of events between a dog or cat bite and a human death attributed to either rabies or to lethal harm associated with the surveillance protocol (e.g., lethal traffic accidents when traveling to veterinary clinics or anti-rabies centers). The results demonstrated that the current French surveillance protocol was not beneficial, as more deaths were generated (traffic accidents) than avoided (by prompt post-exposure prophylaxis administration). We showed here that less stringent risk-based surveillance could prove more appropriate in a French context. The results in this study could allow policy-makers to update and optimize rabies management legislation.https://www.mdpi.com/2306-7381/8/7/132rabiesbitedogcatsurveillancescenario-tree model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guillaume Crozet Tiffany Charmet Florence Cliquet Emmanuelle Robardet Barbara Dufour Julie Rivière |
spellingShingle |
Guillaume Crozet Tiffany Charmet Florence Cliquet Emmanuelle Robardet Barbara Dufour Julie Rivière Benefit–Risk Assessment of the French Surveillance Protocol of Apparently Healthy Biting Dogs and Cats for Human Rabies Prevention Veterinary Sciences rabies bite dog cat surveillance scenario-tree model |
author_facet |
Guillaume Crozet Tiffany Charmet Florence Cliquet Emmanuelle Robardet Barbara Dufour Julie Rivière |
author_sort |
Guillaume Crozet |
title |
Benefit–Risk Assessment of the French Surveillance Protocol of Apparently Healthy Biting Dogs and Cats for Human Rabies Prevention |
title_short |
Benefit–Risk Assessment of the French Surveillance Protocol of Apparently Healthy Biting Dogs and Cats for Human Rabies Prevention |
title_full |
Benefit–Risk Assessment of the French Surveillance Protocol of Apparently Healthy Biting Dogs and Cats for Human Rabies Prevention |
title_fullStr |
Benefit–Risk Assessment of the French Surveillance Protocol of Apparently Healthy Biting Dogs and Cats for Human Rabies Prevention |
title_full_unstemmed |
Benefit–Risk Assessment of the French Surveillance Protocol of Apparently Healthy Biting Dogs and Cats for Human Rabies Prevention |
title_sort |
benefit–risk assessment of the french surveillance protocol of apparently healthy biting dogs and cats for human rabies prevention |
publisher |
MDPI AG |
series |
Veterinary Sciences |
issn |
2306-7381 |
publishDate |
2021-07-01 |
description |
In France, apparently healthy dogs and cats that bite humans must undergo an observation period of 15 days with three veterinary visits to ascertain that they remain healthy, indicating that no zoonotic transmission of rabies virus occurred via salivary presymptomatic excretion. This surveillance protocol is mandatory for all pets that have bitten humans, despite France’s rabies-free status in non-flying mammals (i.e., a very low rabies risk). In this context, we aimed to perform a benefit–risk assessment of the existing regulatory surveillance protocol of apparently healthy biting animals, as well as alternative surveillance protocols. A scenario-tree modelling approach was used to consider the possible successions of events between a dog or cat bite and a human death attributed to either rabies or to lethal harm associated with the surveillance protocol (e.g., lethal traffic accidents when traveling to veterinary clinics or anti-rabies centers). The results demonstrated that the current French surveillance protocol was not beneficial, as more deaths were generated (traffic accidents) than avoided (by prompt post-exposure prophylaxis administration). We showed here that less stringent risk-based surveillance could prove more appropriate in a French context. The results in this study could allow policy-makers to update and optimize rabies management legislation. |
topic |
rabies bite dog cat surveillance scenario-tree model |
url |
https://www.mdpi.com/2306-7381/8/7/132 |
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