Effect of mevalonate analogues upon cholesterol biosynthesis

Effect of mevalonate analogues upon cholesterol biosynthesis

Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > Δ2-3-methyl pentenoic acid > Δ3-3-methyl pentenoic acid. The hydroxy acid produces half the maximum inhibition at a...

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Main Authors: Herbert Weiss, Elliott Schiffmann, Elwood Titus
Format: Article
Language:English
Published: Elsevier 1961-07-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752039012X
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spelling doaj-f4d583ab8e634c97816c41904c3853ed2021-04-23T06:10:49ZengElsevierJournal of Lipid Research0022-22751961-07-0123258262Effect of mevalonate analogues upon cholesterol biosynthesisHerbert Weiss0Elliott Schiffmann1Elwood Titus2Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda 14, MarylandLaboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda 14, MarylandLaboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda 14, MarylandThree analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > Δ2-3-methyl pentenoic acid > Δ3-3-methyl pentenoic acid. The hydroxy acid produces half the maximum inhibition at a concentration of 5 μmoles/ml of homogenate. This corresponds to a ratio of 100 μmoles of inhibitor to 1 μmole of substrate.http://www.sciencedirect.com/science/article/pii/S002222752039012X
collection DOAJ
language English
format Article
sources DOAJ
author Herbert Weiss
Elliott Schiffmann
Elwood Titus
spellingShingle Herbert Weiss
Elliott Schiffmann
Elwood Titus
Effect of mevalonate analogues upon cholesterol biosynthesis
Journal of Lipid Research
author_facet Herbert Weiss
Elliott Schiffmann
Elwood Titus
author_sort Herbert Weiss
title Effect of mevalonate analogues upon cholesterol biosynthesis
title_short Effect of mevalonate analogues upon cholesterol biosynthesis
title_full Effect of mevalonate analogues upon cholesterol biosynthesis
title_fullStr Effect of mevalonate analogues upon cholesterol biosynthesis
title_full_unstemmed Effect of mevalonate analogues upon cholesterol biosynthesis
title_sort effect of mevalonate analogues upon cholesterol biosynthesis
publisher Elsevier
series Journal of Lipid Research
issn 0022-2275
publishDate 1961-07-01
description Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > Δ2-3-methyl pentenoic acid > Δ3-3-methyl pentenoic acid. The hydroxy acid produces half the maximum inhibition at a concentration of 5 μmoles/ml of homogenate. This corresponds to a ratio of 100 μmoles of inhibitor to 1 μmole of substrate.
url http://www.sciencedirect.com/science/article/pii/S002222752039012X
work_keys_str_mv AT herbertweiss effectofmevalonateanaloguesuponcholesterolbiosynthesis
AT elliottschiffmann effectofmevalonateanaloguesuponcholesterolbiosynthesis
AT elwoodtitus effectofmevalonateanaloguesuponcholesterolbiosynthesis
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