Neuroprotective Potential of GDF11: Myth or Reality?
In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been id...
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MDPI AG
2019-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/20/14/3563 |
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doaj-f4e4a9a9f791466d9b3f34a4cbb6413d2020-11-24T20:53:06ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-07-012014356310.3390/ijms20143563ijms20143563Neuroprotective Potential of GDF11: Myth or Reality?Luc Rochette0Gabriel Malka1Equipe d’Accueil (EA 7460), Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Université de Bourgogne—Franche Comté, Faculté des Sciences de Santé, 7 Bd Jeanne d’Arc, 21000 Dijon, FranceInstitut de Formation en Biotechnologie et Ingénierie Biomédicale (IFR2B), Université Mohammed VI Polytechnique, 43 150 Ben-Guerir, MoroccoIn the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a “rejuvenating factor” opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies.https://www.mdpi.com/1422-0067/20/14/3563neuroprotectionrejuvenating factorsGDF11 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Luc Rochette Gabriel Malka |
| spellingShingle |
Luc Rochette Gabriel Malka Neuroprotective Potential of GDF11: Myth or Reality? International Journal of Molecular Sciences neuroprotection rejuvenating factors GDF11 |
| author_facet |
Luc Rochette Gabriel Malka |
| author_sort |
Luc Rochette |
| title |
Neuroprotective Potential of GDF11: Myth or Reality? |
| title_short |
Neuroprotective Potential of GDF11: Myth or Reality? |
| title_full |
Neuroprotective Potential of GDF11: Myth or Reality? |
| title_fullStr |
Neuroprotective Potential of GDF11: Myth or Reality? |
| title_full_unstemmed |
Neuroprotective Potential of GDF11: Myth or Reality? |
| title_sort |
neuroprotective potential of gdf11: myth or reality? |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2019-07-01 |
| description |
In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a “rejuvenating factor” opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies. |
| topic |
neuroprotection rejuvenating factors GDF11 |
| url |
https://www.mdpi.com/1422-0067/20/14/3563 |
| work_keys_str_mv |
AT lucrochette neuroprotectivepotentialofgdf11mythorreality AT gabrielmalka neuroprotectivepotentialofgdf11mythorreality |
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