Baboon syndrome induced by hydroxyzine

• Main Authors: Hayet Akkari, Hichem Belhadjali, Monia Youssef, Sana Mokni, Jamelediine Zili
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2013-01-01
• Series: Indian Journal of Dermatology
• Subjects: Baboon syndrome; drug eruption; hydroxyzine; patch test; symmetrical drug-related intertriginous and flexural exanthema; systemic contact dermatitis
• Online Access: http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=3;spage=244;epage=244;aulast=Akkari
• ISSN: 0019-5154; 1998-3611

Hydroxyzine-induced drug eruptions are very rare. We report here a typical case of drug-related Baboon syndrome or symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) which was induced by hydroxyzine in a 60-year-old man. The diagnosis was confirmed by positive patch and oral accidental provocation tests with hydroxyzine. Patch tests and oral provocation tests with cetirizine and levocetirizine were negative. A review of the literature identified only 17 reported cases of hydroxyzine-induced drug eruptions. To the best of our knowledge, we report here the first case of hydroxyzine-induced SDRIFE.