Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer
Abstract Background Non-small-cell lung cancer (NSCLC) represents 85% of lung cancer cases. Genotyping is now considered as a cornerstone in proper management and better results of such cancers, especially with targeted therapy. Cryobiopsy is a promising tool in NSCLC to obtain larger samples, with...
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doaj-f4edd6a5a6744571b06d231e0108b18a2021-01-24T12:46:25ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512020-01-0113563664310.4103/ejb.ejb_40_19Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancerAhmed S. H. Mohamed0Mohamed Hantera1Ragia S. Sharshar2Amira Y. Abdelnaby3Ayman El Saka4Department of Chest, Faculty of Medicine, Tanta UniversityDepartment of Chest, Faculty of Medicine, Tanta UniversityDepartment of Chest, Faculty of Medicine, Tanta UniversityDepartment of Clinical Pathology, Tanta UniversityDepartment of Pathology, Faculty of Medicine, Tanta UniversityAbstract Background Non-small-cell lung cancer (NSCLC) represents 85% of lung cancer cases. Genotyping is now considered as a cornerstone in proper management and better results of such cancers, especially with targeted therapy. Cryobiopsy is a promising tool in NSCLC to obtain larger samples, with well-preserved tissue sufficient for accurate histopathological and gene detection. Aim To compare cryobiopsy and ordinary forceps results in detection of epidermal growth factor receptor (EGFR) amplification in NSCLC. Materials and methods Samples from 34 patients with proven NSCLC by cryobiopsy versus forceps biopsy were compared for size, quality, and diagnostic yield of EGFR gene amplification. Results The samples obtained by cryoprobe had larger size and better artifact-free areas with more diagnostic yield of EGFR gene amplification (29.4%) versus with forceps biopsy (8.8%), with gene amplification showing higher statistical significance in younger patients, never smokers, and women (P<0.001). Conclusion Cryobiopsy is an excellent tool for larger, better-quality sampling and for higher diagnostic yield of EGFR amplification in NSCLC.https://doi.org/10.4103/ejb.ejb_40_19cryobiopsy epidermal growth factor receptorcryobiopsyEGFRnon-small-cell lung cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ahmed S. H. Mohamed Mohamed Hantera Ragia S. Sharshar Amira Y. Abdelnaby Ayman El Saka |
spellingShingle |
Ahmed S. H. Mohamed Mohamed Hantera Ragia S. Sharshar Amira Y. Abdelnaby Ayman El Saka Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer The Egyptian Journal of Bronchology cryobiopsy epidermal growth factor receptor cryobiopsy EGFR non-small-cell lung cancer |
author_facet |
Ahmed S. H. Mohamed Mohamed Hantera Ragia S. Sharshar Amira Y. Abdelnaby Ayman El Saka |
author_sort |
Ahmed S. H. Mohamed |
title |
Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer |
title_short |
Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer |
title_full |
Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer |
title_fullStr |
Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer |
title_full_unstemmed |
Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer |
title_sort |
comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Bronchology |
issn |
1687-8426 2314-8551 |
publishDate |
2020-01-01 |
description |
Abstract Background Non-small-cell lung cancer (NSCLC) represents 85% of lung cancer cases. Genotyping is now considered as a cornerstone in proper management and better results of such cancers, especially with targeted therapy. Cryobiopsy is a promising tool in NSCLC to obtain larger samples, with well-preserved tissue sufficient for accurate histopathological and gene detection. Aim To compare cryobiopsy and ordinary forceps results in detection of epidermal growth factor receptor (EGFR) amplification in NSCLC. Materials and methods Samples from 34 patients with proven NSCLC by cryobiopsy versus forceps biopsy were compared for size, quality, and diagnostic yield of EGFR gene amplification. Results The samples obtained by cryoprobe had larger size and better artifact-free areas with more diagnostic yield of EGFR gene amplification (29.4%) versus with forceps biopsy (8.8%), with gene amplification showing higher statistical significance in younger patients, never smokers, and women (P<0.001). Conclusion Cryobiopsy is an excellent tool for larger, better-quality sampling and for higher diagnostic yield of EGFR amplification in NSCLC. |
topic |
cryobiopsy epidermal growth factor receptor cryobiopsy EGFR non-small-cell lung cancer |
url |
https://doi.org/10.4103/ejb.ejb_40_19 |
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