Schiff bases and their metal complexes as urease inhibitors – A brief review

Schiff bases and their metal complexes as urease inhibitors – A brief review

Schiff bases, an aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine, are some of the most widely used organic compounds. Indeed, they are widely used for industrial purposes and also exhibit a broad range of biological activities, including anti-urea...

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Main Authors: Ângelo de Fátima, Camila de Paula Pereira, Carolina Raquel Said Dau Gonçalves Olímpio, Breno Germano de Freitas Oliveira, Lucas Lopardi Franco, Pedro Henrique Corrêa da Silva
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Journal of Advanced Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123218300419
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spelling doaj-f50162411d3746bca14f7c9aa9b2ac622020-11-24T23:56:28ZengElsevierJournal of Advanced Research2090-12322018-09-0113113126Schiff bases and their metal complexes as urease inhibitors – A brief reviewÂngelo de Fátima0Camila de Paula Pereira1Carolina Raquel Said Dau Gonçalves Olímpio2Breno Germano de Freitas Oliveira3Lucas Lopardi Franco4Pedro Henrique Corrêa da Silva5Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil; Corresponding author.Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil; Departamento de Alimentos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas, 37130-001 Alfenas, MG, BrazilDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilSchiff bases, an aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine, are some of the most widely used organic compounds. Indeed, they are widely used for industrial purposes and also exhibit a broad range of biological activities, including anti-urease activity. Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms’ health, since the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections. This short review compiles examples of the most antiurease Schiff bases (0.23 μM < IC50 < 37.00 μM) and their metal complexes (0.03 μM < IC50 < 100 μM). Emphasis is given to ureases of Helicobacter pylori and Canavalia ensiformis, although the active site of this class of hydrolases is conserved among living organisms. Keywords: Schiff base, Metal complex, Urea, Urease, Urease inhibitor, Helicobacter pylori, Canavalia ensiformishttp://www.sciencedirect.com/science/article/pii/S2090123218300419
collection DOAJ
language English
format Article
sources DOAJ
author Ângelo de Fátima
Camila de Paula Pereira
Carolina Raquel Said Dau Gonçalves Olímpio
Breno Germano de Freitas Oliveira
Lucas Lopardi Franco
Pedro Henrique Corrêa da Silva
spellingShingle Ângelo de Fátima
Camila de Paula Pereira
Carolina Raquel Said Dau Gonçalves Olímpio
Breno Germano de Freitas Oliveira
Lucas Lopardi Franco
Pedro Henrique Corrêa da Silva
Schiff bases and their metal complexes as urease inhibitors – A brief review
Journal of Advanced Research
author_facet Ângelo de Fátima
Camila de Paula Pereira
Carolina Raquel Said Dau Gonçalves Olímpio
Breno Germano de Freitas Oliveira
Lucas Lopardi Franco
Pedro Henrique Corrêa da Silva
author_sort Ângelo de Fátima
title Schiff bases and their metal complexes as urease inhibitors – A brief review
title_short Schiff bases and their metal complexes as urease inhibitors – A brief review
title_full Schiff bases and their metal complexes as urease inhibitors – A brief review
title_fullStr Schiff bases and their metal complexes as urease inhibitors – A brief review
title_full_unstemmed Schiff bases and their metal complexes as urease inhibitors – A brief review
title_sort schiff bases and their metal complexes as urease inhibitors – a brief review
publisher Elsevier
series Journal of Advanced Research
issn 2090-1232
publishDate 2018-09-01
description Schiff bases, an aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine, are some of the most widely used organic compounds. Indeed, they are widely used for industrial purposes and also exhibit a broad range of biological activities, including anti-urease activity. Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms’ health, since the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections. This short review compiles examples of the most antiurease Schiff bases (0.23 μM < IC50 < 37.00 μM) and their metal complexes (0.03 μM < IC50 < 100 μM). Emphasis is given to ureases of Helicobacter pylori and Canavalia ensiformis, although the active site of this class of hydrolases is conserved among living organisms. Keywords: Schiff base, Metal complex, Urea, Urease, Urease inhibitor, Helicobacter pylori, Canavalia ensiformis
url http://www.sciencedirect.com/science/article/pii/S2090123218300419
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