Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis

Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis

Abstract Background The chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two receptors are present in patients with SSc and are associated with clin...

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Bibliographic Details
Main Authors: Florian Weigold, Jeannine Günther, Moritz Pfeiffenberger, Otavio Cabral-Marques, Elise Siegert, Duska Dragun, Aurélie Philippe, Ann-Katrin Regensburger, Andreas Recke, Xinhua Yu, Frank Petersen, Rusan Catar, Robert Biesen, Falk Hiepe, Gerd R. Burmester, Harald Heidecke, Gabriela Riemekasten
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Arthritis Research & Therapy
Subjects:
Anti-CXCR3
Anti-CXCR4
Systemic sclerosis
Interstitial lung disease
GPCR
Online Access:http://link.springer.com/article/10.1186/s13075-018-1545-8

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http://link.springer.com/article/10.1186/s13075-018-1545-8

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