Hydrogel as a bioactive material to regulate stem cell fate
The encapsulation of stem cells in a hydrogel substrate provides a promising future in biomedical applications. However, communications between hydrogels and stem cells is complicated; various factors such as porosity, different polymer types, stiffness, compatibility and degradation will lead to st...
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KeAi Communications Co., Ltd.
2016-09-01
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X1630010X |
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doaj-f50e5431994d4739becd67596412d6ca2021-03-02T10:20:42ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2016-09-0111395510.1016/j.bioactmat.2016.05.001Hydrogel as a bioactive material to regulate stem cell fateYung-Hao TsouJoe KhoneisserPing-Chun HuangXiaoyang XuThe encapsulation of stem cells in a hydrogel substrate provides a promising future in biomedical applications. However, communications between hydrogels and stem cells is complicated; various factors such as porosity, different polymer types, stiffness, compatibility and degradation will lead to stem cell survival or death. Hydrogels mimic the three-dimensional extracellular matrix to provide a friendly environment for stem cells. On the other hand, stem cells can sense the surroundings to make the next progression, stretching out, proliferating or just to remain. As such, understanding the correlation between stem cells and hydrogels is crucial. In this Review, we first discuss the varying types of the hydrogels and stem cells, which are most commonly used in the biomedical fields and further investigate how hydrogels interact with stem cells from the perspective of their biomedical application, while providing insights into the design and development of hydrogels for drug delivery, tissue engineering and regenerative medicine purpose. In addition, we compare the results such as stiffness, degradation time and pore size as well as peptide types of hydrogels from respected journals. We also discussed most recently magnificent materials and their effects to regulate stem cell fate.http://www.sciencedirect.com/science/article/pii/S2452199X1630010XHydrogelStem cellBiomaterial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yung-Hao Tsou Joe Khoneisser Ping-Chun Huang Xiaoyang Xu |
spellingShingle |
Yung-Hao Tsou Joe Khoneisser Ping-Chun Huang Xiaoyang Xu Hydrogel as a bioactive material to regulate stem cell fate Bioactive Materials Hydrogel Stem cell Biomaterial |
author_facet |
Yung-Hao Tsou Joe Khoneisser Ping-Chun Huang Xiaoyang Xu |
author_sort |
Yung-Hao Tsou |
title |
Hydrogel as a bioactive material to regulate stem cell fate |
title_short |
Hydrogel as a bioactive material to regulate stem cell fate |
title_full |
Hydrogel as a bioactive material to regulate stem cell fate |
title_fullStr |
Hydrogel as a bioactive material to regulate stem cell fate |
title_full_unstemmed |
Hydrogel as a bioactive material to regulate stem cell fate |
title_sort |
hydrogel as a bioactive material to regulate stem cell fate |
publisher |
KeAi Communications Co., Ltd. |
series |
Bioactive Materials |
issn |
2452-199X |
publishDate |
2016-09-01 |
description |
The encapsulation of stem cells in a hydrogel substrate provides a promising future in biomedical applications. However, communications between hydrogels and stem cells is complicated; various factors such as porosity, different polymer types, stiffness, compatibility and degradation will lead to stem cell survival or death. Hydrogels mimic the three-dimensional extracellular matrix to provide a friendly environment for stem cells. On the other hand, stem cells can sense the surroundings to make the next progression, stretching out, proliferating or just to remain. As such, understanding the correlation between stem cells and hydrogels is crucial. In this Review, we first discuss the varying types of the hydrogels and stem cells, which are most commonly used in the biomedical fields and further investigate how hydrogels interact with stem cells from the perspective of their biomedical application, while providing insights into the design and development of hydrogels for drug delivery, tissue engineering and regenerative medicine purpose. In addition, we compare the results such as stiffness, degradation time and pore size as well as peptide types of hydrogels from respected journals. We also discussed most recently magnificent materials and their effects to regulate stem cell fate. |
topic |
Hydrogel Stem cell Biomaterial |
url |
http://www.sciencedirect.com/science/article/pii/S2452199X1630010X |
work_keys_str_mv |
AT yunghaotsou hydrogelasabioactivematerialtoregulatestemcellfate AT joekhoneisser hydrogelasabioactivematerialtoregulatestemcellfate AT pingchunhuang hydrogelasabioactivematerialtoregulatestemcellfate AT xiaoyangxu hydrogelasabioactivematerialtoregulatestemcellfate |
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1724237111260872704 |