Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis
Miliary shadows on chest imaging have wide differential diagnoses. The most common etiology is infectious, such as miliary tuberculosis (TB) and histoplasmosis, but miliary shadows can be the presentation of sarcoidosis, pneumoconiosis, and secondary metastasis to the lungs from primary cancers of t...
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doaj-f5134f24ec61427a82b429ccd5c1c6e42020-11-25T01:28:35ZengKarger PublishersCase Reports in Oncology1662-65752020-02-0113113914410.1159/000505685505685Adenocarcinoma of the Lung Mimicking Miliary TuberculosisDawlat KhanMohammed DanjumaMuhammad Umar SaddiqueKhaled Abdelfattah Hasan MurshedMohamed A. YassinMiliary shadows on chest imaging have wide differential diagnoses. The most common etiology is infectious, such as miliary tuberculosis (TB) and histoplasmosis, but miliary shadows can be the presentation of sarcoidosis, pneumoconiosis, and secondary metastasis to the lungs from primary cancers of the thyroid, kidney, and trophoblasts as well as sarcomas. Here we present the case of a 35-year-old Indian male who presented with a 2-month history of dry cough and shortness of breath. Chest imaging showed diffuse bilateral miliary nodules. The initial impression was that of miliary pulmonary TB. Subsequent bronchoscopy with a transbronchial biopsy confirmed the diagnosis of pulmonary mucinous adenocarcinoma with brain metastasis, which is a rare and unusual presentation of primary lung cancer. The tumor was positive for ALK5A4 and PD-L1, and the patient was started on tyrosine kinase inhibitor immunotherapy, with a favorable response.https://www.karger.com/Article/FullText/505685miliary shadows/patternmiliary tuberculosisadenocarcinomaintrapulmonary metastases. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dawlat Khan Mohammed Danjuma Muhammad Umar Saddique Khaled Abdelfattah Hasan Murshed Mohamed A. Yassin |
spellingShingle |
Dawlat Khan Mohammed Danjuma Muhammad Umar Saddique Khaled Abdelfattah Hasan Murshed Mohamed A. Yassin Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis Case Reports in Oncology miliary shadows/pattern miliary tuberculosis adenocarcinoma intrapulmonary metastases. |
author_facet |
Dawlat Khan Mohammed Danjuma Muhammad Umar Saddique Khaled Abdelfattah Hasan Murshed Mohamed A. Yassin |
author_sort |
Dawlat Khan |
title |
Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis |
title_short |
Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis |
title_full |
Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis |
title_fullStr |
Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis |
title_full_unstemmed |
Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis |
title_sort |
adenocarcinoma of the lung mimicking miliary tuberculosis |
publisher |
Karger Publishers |
series |
Case Reports in Oncology |
issn |
1662-6575 |
publishDate |
2020-02-01 |
description |
Miliary shadows on chest imaging have wide differential diagnoses. The most common etiology is infectious, such as miliary tuberculosis (TB) and histoplasmosis, but miliary shadows can be the presentation of sarcoidosis, pneumoconiosis, and secondary metastasis to the lungs from primary cancers of the thyroid, kidney, and trophoblasts as well as sarcomas. Here we present the case of a 35-year-old Indian male who presented with a 2-month history of dry cough and shortness of breath. Chest imaging showed diffuse bilateral miliary nodules. The initial impression was that of miliary pulmonary TB. Subsequent bronchoscopy with a transbronchial biopsy confirmed the diagnosis of pulmonary mucinous adenocarcinoma with brain metastasis, which is a rare and unusual presentation of primary lung cancer. The tumor was positive for ALK5A4 and PD-L1, and the patient was started on tyrosine kinase inhibitor immunotherapy, with a favorable response. |
topic |
miliary shadows/pattern miliary tuberculosis adenocarcinoma intrapulmonary metastases. |
url |
https://www.karger.com/Article/FullText/505685 |
work_keys_str_mv |
AT dawlatkhan adenocarcinomaofthelungmimickingmiliarytuberculosis AT mohammeddanjuma adenocarcinomaofthelungmimickingmiliarytuberculosis AT muhammadumarsaddique adenocarcinomaofthelungmimickingmiliarytuberculosis AT khaledabdelfattahhasanmurshed adenocarcinomaofthelungmimickingmiliarytuberculosis AT mohamedayassin adenocarcinomaofthelungmimickingmiliarytuberculosis |
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1725100728605736960 |