Calcium in the Backstage of Malaria Parasite Biology
The calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a central role in the parasite life cycle. It has been associated with parasite development, fertilization, locomotion, and host cel...
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doaj-f5142d749cdb4a17bc3fe90379d2ccda2021-07-28T11:34:10ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-07-011110.3389/fcimb.2021.708834708834Calcium in the Backstage of Malaria Parasite BiologyLucas Silva de Oliveira0Lucas Silva de Oliveira1Marcos Rodrigo Alborghetti2Marcos Rodrigo Alborghetti3Renata Garcia Carneiro4Izabela Marques Dourado Bastos5Rogerio Amino6Philippe Grellier7Sébastien Charneau8Laboratory of Biochemistry and Protein Chemistry, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasilia, BrazilUMR 7245 MCAM, Molécules de Communication et Adaptation des Micro-organismes, Muséum National d’Histoire Naturelle, CNRS, Équipe Parasites et Protistes Libres, Paris, FranceLaboratory of Biochemistry and Protein Chemistry, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasilia, BrazilBrazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, BrazilLaboratory of Biochemistry and Protein Chemistry, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasilia, BrazilLaboratory of Host-Pathogen Interaction, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasilia, BrazilUnité Infection et Immunité Paludéennes, Institut Pasteur, Paris, FranceUMR 7245 MCAM, Molécules de Communication et Adaptation des Micro-organismes, Muséum National d’Histoire Naturelle, CNRS, Équipe Parasites et Protistes Libres, Paris, FranceLaboratory of Biochemistry and Protein Chemistry, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasilia, BrazilThe calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a central role in the parasite life cycle. It has been associated with parasite development, fertilization, locomotion, and host cell infection. Despite the lack of a canonical inositol-1,4,5-triphosphate receptor gene in the Plasmodium genome, pharmacological evidence indicates that inositol-1,4,5-triphosphate triggers Ca2+ mobilization from the endoplasmic reticulum. Other structures such as acidocalcisomes, food vacuole and mitochondria are proposed to act as supplementary intracellular Ca2+ reservoirs. Several Ca2+-binding proteins (CaBPs) trigger downstream signaling. Other proteins with no EF-hand motifs, but apparently involved with CaBPs, are depicted as playing an important role in the erythrocyte invasion and egress. It is also proposed that a cross-talk among kinases, which are not members of the family of Ca2+-dependent protein kinases, such as protein kinases G, A and B, play additional roles mediated indirectly by Ca2+ regulation. This statement may be extended for proteins directly related to invasion or egress, such as SUB1, ERC, IMC1I, IMC1g, GAP45 and EBA175. In this review, we update our understanding of aspects of Ca2+-mediated signaling correlated to the developmental stages of the malaria parasite life cycle.https://www.frontiersin.org/articles/10.3389/fcimb.2021.708834/fullCa2+ signalingPlasmodiumintracellular messengerhomeostasisinvasionegress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucas Silva de Oliveira Lucas Silva de Oliveira Marcos Rodrigo Alborghetti Marcos Rodrigo Alborghetti Renata Garcia Carneiro Izabela Marques Dourado Bastos Rogerio Amino Philippe Grellier Sébastien Charneau |
spellingShingle |
Lucas Silva de Oliveira Lucas Silva de Oliveira Marcos Rodrigo Alborghetti Marcos Rodrigo Alborghetti Renata Garcia Carneiro Izabela Marques Dourado Bastos Rogerio Amino Philippe Grellier Sébastien Charneau Calcium in the Backstage of Malaria Parasite Biology Frontiers in Cellular and Infection Microbiology Ca2+ signaling Plasmodium intracellular messenger homeostasis invasion egress |
author_facet |
Lucas Silva de Oliveira Lucas Silva de Oliveira Marcos Rodrigo Alborghetti Marcos Rodrigo Alborghetti Renata Garcia Carneiro Izabela Marques Dourado Bastos Rogerio Amino Philippe Grellier Sébastien Charneau |
author_sort |
Lucas Silva de Oliveira |
title |
Calcium in the Backstage of Malaria Parasite Biology |
title_short |
Calcium in the Backstage of Malaria Parasite Biology |
title_full |
Calcium in the Backstage of Malaria Parasite Biology |
title_fullStr |
Calcium in the Backstage of Malaria Parasite Biology |
title_full_unstemmed |
Calcium in the Backstage of Malaria Parasite Biology |
title_sort |
calcium in the backstage of malaria parasite biology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2021-07-01 |
description |
The calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a central role in the parasite life cycle. It has been associated with parasite development, fertilization, locomotion, and host cell infection. Despite the lack of a canonical inositol-1,4,5-triphosphate receptor gene in the Plasmodium genome, pharmacological evidence indicates that inositol-1,4,5-triphosphate triggers Ca2+ mobilization from the endoplasmic reticulum. Other structures such as acidocalcisomes, food vacuole and mitochondria are proposed to act as supplementary intracellular Ca2+ reservoirs. Several Ca2+-binding proteins (CaBPs) trigger downstream signaling. Other proteins with no EF-hand motifs, but apparently involved with CaBPs, are depicted as playing an important role in the erythrocyte invasion and egress. It is also proposed that a cross-talk among kinases, which are not members of the family of Ca2+-dependent protein kinases, such as protein kinases G, A and B, play additional roles mediated indirectly by Ca2+ regulation. This statement may be extended for proteins directly related to invasion or egress, such as SUB1, ERC, IMC1I, IMC1g, GAP45 and EBA175. In this review, we update our understanding of aspects of Ca2+-mediated signaling correlated to the developmental stages of the malaria parasite life cycle. |
topic |
Ca2+ signaling Plasmodium intracellular messenger homeostasis invasion egress |
url |
https://www.frontiersin.org/articles/10.3389/fcimb.2021.708834/full |
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