Familial localized scleroderma with paediatric onset: a review

• Main Authors: Ida Yurtsever, Małgorzata Łukomska, Piotr Sobolewski, Elżbieta Szymańska, Witold Owczarek, Irena Walecka
• Format: Article
• Language: English
• Published: Termedia Publishing House 2021-05-01
• Series: Advances in Dermatology and Allergology
• Subjects: morphea; localized scleroderma; familial; paediatric onset; juvenile
• Online Access: https://www.termedia.pl/Familial-localized-scleroderma-with-paediatric-onset-a-review,7,44091,1,1.html

Localized scleroderma is an inflammatory disease causing sclerosis of the skin. The aetiology and pathogenesis of localized scleroderma remain unclear. Localized scleroderma is considered a genetically driven disease. It is not well understood if genetic factors or environmental exposure individually can cause its development or if their interaction is needed to trigger the disease. Some authors postulate that familial clustering is evidence of a hereditary disease. Familial localized scleroderma has been rarely reported and is a case worth studying. We present the review of literature on this subject with 3 additional cases of familial localized scleroderma with paediatric onset.