Agriophyllum Oligosaccharides Ameliorate Diabetic Insulin Resistance Through INS-R/IRS/Glut4-Mediated Insulin Pathway in db/db Mice and MIN6 Cells

Agriophyllum Oligosaccharides Ameliorate Diabetic Insulin Resistance Through INS-R/IRS/Glut4-Mediated Insulin Pathway in db/db Mice and MIN6 Cells

We have previously reported that Agriophyllum oligosaccharides (AOS) significantly enhance glycemic control by increasing the activation of insulin receptor (INS-R), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3 kinase (PI3K), protein kinase B (AKT), peroxisome proliferator-activated...

Full description

Bibliographic Details
Main Authors:	Shuyin Bao, Xiuzhi Wang, Sung Bo Cho, Yan-Ling Wu, Chengxi Wei, Shuying Han, Liming Bao, Qiong Wu, Wuliji Ao, Ji-Xing Nan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Pharmacology
Subjects:	Agriophyllum oligosaccharides (AOS) T2DM insulin resistance INS-R/IRS/Glut4 insulin pathway db/db mice
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.656220/full

Similar Items

1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice
by: Qingpu Liu, et al.
Published: (2015-12-01)

The Effect of Chrysin-Loaded Phytosomes on Insulin Resistance and Blood Sugar Control in Type 2 Diabetic db/db Mice
by: Seong-min Kim, et al.
Published: (2020-11-01)

Effects of D-Chiro-Inositol on Glucose Metabolism in db/db Mice and the Associated Underlying Mechanisms
by: Chunxue Fan, et al.
Published: (2020-03-01)

Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway
by: Liwen Zhang, et al.
Published: (2019-04-01)

Impact of Insulin Resistance on Behavioral and Neurochemical Deficits in db/db Mice
by: Sharma, Ajaykumar Narayan
Published: (2011)

Therapeutic potential of buckwheat hull flavonoids in db/db mice, a model of type 2 diabetes
by: Pengcheng Li, et al.
Published: (2019-01-01)

Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice
by: Guang Chen, et al.
Published: (2020-09-01)

Honokiol Improves Insulin Resistance, Hepatic Steatosis, and Inflammation in Type 2 Diabetic <i>db</i>/<i>db</i> Mice
by: Young-Je Kim, et al.
Published: (2019-05-01)

Effects of sea buckthorn (Hippophaë rhamnoides) juice and L-quebrachitol on type 2 diabetes mellitus in db/db mice
by: Yong Xue, et al.
Published: (2015-06-01)

T0901317 improves renal injury in db/db mice by activating liver X receptor α
by: WU Song, et al.
Published: (2020-01-01)

Dietary Leucine Supplement Ameliorates Hepatic Steatosis and Diabetic Nephropathy in db/db Mice
by: Kuan-Hsing Chen, et al.
Published: (2018-06-01)

Bark of Passiflora edulis Treatment Stimulates Antioxidant Capacity, and Reduces Dyslipidemia and Body Fat in db/db Mice
by: Marielle Fernanda Panelli, et al.
Published: (2018-09-01)

Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice
by: Katsunori Nonogaki, et al.
Published: (2020-12-01)

Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice
by: Eunjin Lim, et al.
Published: (2016-12-01)

Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice
by: Noura B. El Khoury, et al.
Published: (2016-04-01)

Differential Proteomic Analysis of the Pancreas of Diabetic db/db Mice Reveals the Proteins Involved in the Development of Complications of Diabetes Mellitus
by: Victoriano Pérez-Vázquez, et al.
Published: (2014-05-01)

Leptin Receptor-Deficient db/db Mice Show Significant Heterogeneity in Response to High Non-heme Iron Diet
by: Sabine Paeschke, et al.
Published: (2021-09-01)

Active Time-Restricted Feeding Improved Sleep-Wake Cycle in db/db Mice
by: Tianfei Hou, et al.
Published: (2019-09-01)

A comparison between MongoDB & CouchDB on search performance : A comparative analysis
by: Kinnander, Mathias
Published: (2018)

Renoprotective Effect of Formononetin by Suppressing Smad3 Expression in Db/Db Mice
by: Lv J, et al.
Published: (2020-09-01)

Hydrogen sulfide improves vessel formation of the ischemic adductor muscle and wound healing in diabetic db/db mice
by: Guo-Guang Wang, et al.
Published: (2019-10-01)

Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice
by: Zhu Y, et al.
Published: (2019-10-01)

1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice
by: Qingpu Liu, et al.
Published: (2016-02-01)

SSR-based evaluation of genetic diversity in populations of Agriophyllum squarrosum L. and Agriophyllum minus Fisch. & Mey. collected in South-East Kazakhstan
by: Y. Genievskaya, et al.
Published: (2020-12-01)

Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
by: Guankui Du, et al.

En Komparativ Studie av Arkitekturen hos två NewSQL Databaser : En undersökning av VoltDB och CockroachDB
by: Berg, Kim, et al.
Published: (2021)

Systemic TNF-α blockade attenuates anxiety and depressive-like behaviors in db/db mice through downregulation of inflammatory signaling in peripheral immune cells
by: Musaad A. Alshammari, et al.
Published: (2020-05-01)

Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San in db/db Mice via Activation of PI3K/Akt and AMPK Pathways
by: Bailu Duan, et al.
Published: (2017-08-01)

Dietary Supplement of Large Yellow Tea Ameliorates Metabolic Syndrome and Attenuates Hepatic Steatosis in db/db Mice
by: Yun Teng, et al.
Published: (2018-01-01)

Gender-Dependent Alteration of Ca2+ and TNFα Signaling in db/db Mice, an Obesity-Linked Type 2 Diabetic Model
by: Carmen Delgado, et al.
Published: (2019-02-01)

Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice
by: Hung-Wen Liu, et al.
Published: (2019-04-01)

Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin
by: Francesco Suriano, et al.
Published: (2021-06-01)

Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice
by: Leonid M. Yermakov, et al.
Published: (2018-06-01)

Blood-Glucose-Lowering Effect of Coptidis Rhizoma Extracts From Different Origins via Gut Microbiota Modulation in db/db Mice
by: Yuanfeng Lyu, et al.
Published: (2021-06-01)

Gut Microbial Changes in Diabetic db/db Mice and Recovery of Microbial Diversity upon Pirfenidone Treatment
by: Harinder Singh, et al.
Published: (2020-09-01)

Phyllodulcin, a natural functional sweetener, improves diabetic metabolic changes by regulating hepatic lipogenesis, inflammation, oxidative stress, fibrosis, and gluconeogenesis in db/db mice
by: Eunju Kim, et al.
Published: (2018-03-01)

Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression
by: Bin Zhang, et al.
Published: (2019-01-01)

The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice
by: Tabusi Manaer, et al.
Published: (2021-04-01)

Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways
by: Xiaolin Bai, et al.
Published: (2020-09-01)

Morphological description and DNA barcoding study of sand rice (Agriophyllum squarrosum, Chenopodiaceae) collected in Kazakhstan
by: Yuliya Genievskaya, et al.
Published: (2017-11-01)