Association of HCV Infection with C-Reactive Protein: National Health and Nutrition Examination Survey (NHANES), 2009–2010
The relationship between hepatitis C virus (HCV) infection and C-reactive protein (CRP), which is an inflammatory biomarker, is limited in studies with the general population. It was hypothesized that changes in CRP levels are genotype-dependent in the general population with HCV infection. Thus, th...
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doaj-f559d1dd3b9a4f3d83ab6fd8128c863e2020-11-24T23:55:40ZengMDPI AGDiseases2079-97212019-02-01712510.3390/diseases7010025diseases7010025Association of HCV Infection with C-Reactive Protein: National Health and Nutrition Examination Survey (NHANES), 2009–2010Azad R. Bhuiyan0Amal K. Mitra1Oluwabunmi Ogungbe2Nusrat Kabir3Department of Epidemiology and Biostatistics, School of Public Health, Jackson State University, Jackson, MS 39213, USADepartment of Epidemiology and Biostatistics, School of Public Health, Jackson State University, Jackson, MS 39213, USADepartment of Epidemiology and Biostatistics, School of Public Health, Jackson State University, Jackson, MS 39213, USADepartment of Epidemiology and Biostatistics, School of Public Health, Jackson State University, Jackson, MS 39213, USAThe relationship between hepatitis C virus (HCV) infection and C-reactive protein (CRP), which is an inflammatory biomarker, is limited in studies with the general population. It was hypothesized that changes in CRP levels are genotype-dependent in the general population with HCV infection. Thus, this study aimed to assess the prevalence of HCV infection and compare CRP levels with an anti-HCV antibody, HCV-RNA status, and HCV genotypes. A total of 5611 adult participants from the National and Health Nutrition Examination (NHANES), 2009⁻2010 survey were analyzed. Proc survey frequency, means, and multivariate regression were used due to the complex survey design of NHANES. The prevalence of HCV infection among the study population was 1.6%. There were lower mean CRP levels among people with anti-HCV antibody positive status compared to those with antibody negative status (0.12 ± 0.08 vs. 0.24 ± 0.02, <i>p</i> = 0.08, 95% Confidence Intervals, CI: −1.12 to 0.07). Mean CRP levels were also lower in people with HCV-RNA positive status compared to those with HCV-RNA negative status (0.56 ± 0.03 vs. 0.48 ± 0.05, <i>p</i> = 0.62 and 95% CI: −1.37 to 0.86). However, these differences were non-significant. With respect to HCV genotypes, significantly higher CRP levels were noted among people infected with HCV genotype 2 vs. genotype 1 (0.53 ± 0.06 vs. 0.23 ± 0.05, <i>p</i> < 0.01, 95% CI: −0.58 to −0.02) and those with HCV genotype 2 vs. HCV genotype 3 (0.53 ± 0.06, 0.28 ± 0.04, <i>p</i> < 0.01, 95% CI: 0.02 to 0.48). Further studies are needed to confirm this finding.https://www.mdpi.com/2079-9721/7/1/25hepatitis C virusC-reactive proteinHCV-RNAinflammationNHANES data |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Azad R. Bhuiyan Amal K. Mitra Oluwabunmi Ogungbe Nusrat Kabir |
spellingShingle |
Azad R. Bhuiyan Amal K. Mitra Oluwabunmi Ogungbe Nusrat Kabir Association of HCV Infection with C-Reactive Protein: National Health and Nutrition Examination Survey (NHANES), 2009–2010 Diseases hepatitis C virus C-reactive protein HCV-RNA inflammation NHANES data |
author_facet |
Azad R. Bhuiyan Amal K. Mitra Oluwabunmi Ogungbe Nusrat Kabir |
author_sort |
Azad R. Bhuiyan |
title |
Association of HCV Infection with C-Reactive Protein: National Health and Nutrition Examination Survey (NHANES), 2009–2010 |
title_short |
Association of HCV Infection with C-Reactive Protein: National Health and Nutrition Examination Survey (NHANES), 2009–2010 |
title_full |
Association of HCV Infection with C-Reactive Protein: National Health and Nutrition Examination Survey (NHANES), 2009–2010 |
title_fullStr |
Association of HCV Infection with C-Reactive Protein: National Health and Nutrition Examination Survey (NHANES), 2009–2010 |
title_full_unstemmed |
Association of HCV Infection with C-Reactive Protein: National Health and Nutrition Examination Survey (NHANES), 2009–2010 |
title_sort |
association of hcv infection with c-reactive protein: national health and nutrition examination survey (nhanes), 2009–2010 |
publisher |
MDPI AG |
series |
Diseases |
issn |
2079-9721 |
publishDate |
2019-02-01 |
description |
The relationship between hepatitis C virus (HCV) infection and C-reactive protein (CRP), which is an inflammatory biomarker, is limited in studies with the general population. It was hypothesized that changes in CRP levels are genotype-dependent in the general population with HCV infection. Thus, this study aimed to assess the prevalence of HCV infection and compare CRP levels with an anti-HCV antibody, HCV-RNA status, and HCV genotypes. A total of 5611 adult participants from the National and Health Nutrition Examination (NHANES), 2009⁻2010 survey were analyzed. Proc survey frequency, means, and multivariate regression were used due to the complex survey design of NHANES. The prevalence of HCV infection among the study population was 1.6%. There were lower mean CRP levels among people with anti-HCV antibody positive status compared to those with antibody negative status (0.12 ± 0.08 vs. 0.24 ± 0.02, <i>p</i> = 0.08, 95% Confidence Intervals, CI: −1.12 to 0.07). Mean CRP levels were also lower in people with HCV-RNA positive status compared to those with HCV-RNA negative status (0.56 ± 0.03 vs. 0.48 ± 0.05, <i>p</i> = 0.62 and 95% CI: −1.37 to 0.86). However, these differences were non-significant. With respect to HCV genotypes, significantly higher CRP levels were noted among people infected with HCV genotype 2 vs. genotype 1 (0.53 ± 0.06 vs. 0.23 ± 0.05, <i>p</i> < 0.01, 95% CI: −0.58 to −0.02) and those with HCV genotype 2 vs. HCV genotype 3 (0.53 ± 0.06, 0.28 ± 0.04, <i>p</i> < 0.01, 95% CI: 0.02 to 0.48). Further studies are needed to confirm this finding. |
topic |
hepatitis C virus C-reactive protein HCV-RNA inflammation NHANES data |
url |
https://www.mdpi.com/2079-9721/7/1/25 |
work_keys_str_mv |
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