Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine
Due to the addressability and programmability, DNA has been applied not merely in constructing static elegant nanostructures such as two dimensional and three dimensional DNA nanostructures but also in designing dynamic nanodevices. Moreover, DNA could combine with hydrophobic organic molecules to b...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-08-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/19/8/2283 |
id |
doaj-f55d76c1cbd44d1c83e3c51f7f24fe8f |
---|---|
record_format |
Article |
spelling |
doaj-f55d76c1cbd44d1c83e3c51f7f24fe8f2020-11-24T22:49:52ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-08-01198228310.3390/ijms19082283ijms19082283Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in BiomedicineZhiyong Zhao0Ting Du1Feng Liang2Simin Liu3The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, ChinaThe State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, ChinaThe State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, ChinaThe State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, ChinaDue to the addressability and programmability, DNA has been applied not merely in constructing static elegant nanostructures such as two dimensional and three dimensional DNA nanostructures but also in designing dynamic nanodevices. Moreover, DNA could combine with hydrophobic organic molecules to be a new amphiphilic building block and then self-assemble into nanomaterials. Of particular note, a recent state-of-the-art research has turned our attention to the amphiphilic DNA organic hybrids including small molecule modified DNA (lipid-DNA, fluorescent molecule-DNA, etc.), DNA block copolymers, and DNA-dendron hybrids. This review focuses mainly on the development of their self-assembly behavior and their potential application in nanomaterial and biomedicine. The potential challenges regarding of the amphiphilic DNA organic hybrids are also briefly discussed, aiming to advance their practical applications in nanoscience and biomedicine.http://www.mdpi.com/1422-0067/19/8/2283small molecule modified DNADNA block copolymersDNA-dendron hybridsself-assemblynanostructurenanosciencebiomedicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhiyong Zhao Ting Du Feng Liang Simin Liu |
spellingShingle |
Zhiyong Zhao Ting Du Feng Liang Simin Liu Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine International Journal of Molecular Sciences small molecule modified DNA DNA block copolymers DNA-dendron hybrids self-assembly nanostructure nanoscience biomedicine |
author_facet |
Zhiyong Zhao Ting Du Feng Liang Simin Liu |
author_sort |
Zhiyong Zhao |
title |
Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine |
title_short |
Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine |
title_full |
Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine |
title_fullStr |
Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine |
title_full_unstemmed |
Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine |
title_sort |
amphiphilic dna organic hybrids: functional materials in nanoscience and potential application in biomedicine |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-08-01 |
description |
Due to the addressability and programmability, DNA has been applied not merely in constructing static elegant nanostructures such as two dimensional and three dimensional DNA nanostructures but also in designing dynamic nanodevices. Moreover, DNA could combine with hydrophobic organic molecules to be a new amphiphilic building block and then self-assemble into nanomaterials. Of particular note, a recent state-of-the-art research has turned our attention to the amphiphilic DNA organic hybrids including small molecule modified DNA (lipid-DNA, fluorescent molecule-DNA, etc.), DNA block copolymers, and DNA-dendron hybrids. This review focuses mainly on the development of their self-assembly behavior and their potential application in nanomaterial and biomedicine. The potential challenges regarding of the amphiphilic DNA organic hybrids are also briefly discussed, aiming to advance their practical applications in nanoscience and biomedicine. |
topic |
small molecule modified DNA DNA block copolymers DNA-dendron hybrids self-assembly nanostructure nanoscience biomedicine |
url |
http://www.mdpi.com/1422-0067/19/8/2283 |
work_keys_str_mv |
AT zhiyongzhao amphiphilicdnaorganichybridsfunctionalmaterialsinnanoscienceandpotentialapplicationinbiomedicine AT tingdu amphiphilicdnaorganichybridsfunctionalmaterialsinnanoscienceandpotentialapplicationinbiomedicine AT fengliang amphiphilicdnaorganichybridsfunctionalmaterialsinnanoscienceandpotentialapplicationinbiomedicine AT siminliu amphiphilicdnaorganichybridsfunctionalmaterialsinnanoscienceandpotentialapplicationinbiomedicine |
_version_ |
1725674690419097600 |