Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway

<p>Abstract</p> <p>Background</p> <p>The antiangiogenic agent cilengitide disrupts integrin binding to the extracellular matrix leading to apoptosis of activated endothelial cells. Integrins are also widely expressed in malignant glioma and integrin inhibitors may direc...

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Bibliographic Details
Main Authors:	Nippgen Johannes, Bokemeyer Carsten, Fiedler Walter, Hauschild Jessica, Oliveira-Ferrer Leticia, Celik Ilhan, Schuch Gunter
Format:	Article
Language:	English
Published:	BMC 2008-12-01
Series:	Journal of Experimental & Clinical Cancer Research
Online Access:	http://www.jeccr.com/content/27/1/86

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