Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP®
Background: Bird antigens are some of the most relevant antigens in hypersensitivity pneumonitis (HP). Possible sources of bird antigens are bird breeding, feather products and fertilizer with fowl droppings. For the screening and diagnosis of HP, the measurement of bird-specific antibodies should b...
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doaj-f5725c167e6a41fe9fbc2d732051f7082021-03-25T04:27:10ZengElsevierAllergology International1323-89302021-04-01702208214Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP®Tsuyoshi Shirai0Yoshinori Tanino1Takefumi Nikaido2Yotaro Takaku3Seishu Hashimoto4Yoshio Taguchi5Tomohisa Baba6Takashi Ogura7Kensuke Kataoka8Masayuki Nakayama9Yoshihito Yamada10Sayomi Matsushima11Satoshi Nakayama12Yasunari Miyazaki13Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima, JapanDepartment of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima, JapanDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, JapanDepartment of Respiratory Medicine, Tenri Hospital, Nara, JapanDepartment of Respiratory Medicine, Tenri Hospital, Nara, JapanDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Kanagawa, JapanDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Kanagawa, JapanDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Aichi, JapanDivision of Pulmonary Medicine, Department of Medicine Jichi Medical University, Tochigi, JapanDepartment of Respiratory Medicine, JR Tokyo General Hospital, Tokyo, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanImmuno Diagnostic Division, Thermo Fisher Scientific, Tokyo, JapanDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Corresponding author. Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519 Japan.Background: Bird antigens are some of the most relevant antigens in hypersensitivity pneumonitis (HP). Possible sources of bird antigens are bird breeding, feather products and fertilizer with fowl droppings. For the screening and diagnosis of HP, the measurement of bird-specific antibodies should be standardized. The aim of this study was to clarify the utility of serum IgG (sIgG) and IgA (sIgA) antibodies to bird antigens in screening and diagnosing acute/chronic bird-related HP with ImmunoCAP® in multi-centre clinical research. Methods: We executed a clinical performance test by conducting a multi-institutional study to measure the levels of sIgG/sIgA against pigeon, parrot and budgerigar antigens by the ImmunoCAP® system in 29 acute and 46 chronic bird-related HP patients. Results: The levels of sIgG/sIgA against the bird antigens of the three species were significantly higher in subjects with acute bird-related HP and chronic bird-related HP with acute episodes (recurrent type) than in the control subjects. For sIgG, the optimal cutoff values by receiver operating characteristic (ROC) analysis were 24.6 mgA/L for pigeon, 14.0 mgA/L for parrot, and 8.7 mgA/L for budgerigar. By measuring multiple bird antigens and combining sIgG values of two species, the sensitivity and specificity for acute and recurrent-type chronic bird-related HP patients were 85–91% and 73–80%, respectively. For recurrent and insidious types of chronic bird-related HP, the sensitivity and specificity were 48–61% and 73–80%, respectively. Conclusions: Measurement of the levels of sIgG/sIgA against pigeon, budgerigar and parrot antigens by ImmunoCAP® was useful for screening and diagnosis in bird-related HP.http://www.sciencedirect.com/science/article/pii/S1323893020301283Bird antigenHypersensitivity pneumonitisImmunoCAP®ScreeningSpecific antigen |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tsuyoshi Shirai Yoshinori Tanino Takefumi Nikaido Yotaro Takaku Seishu Hashimoto Yoshio Taguchi Tomohisa Baba Takashi Ogura Kensuke Kataoka Masayuki Nakayama Yoshihito Yamada Sayomi Matsushima Satoshi Nakayama Yasunari Miyazaki |
spellingShingle |
Tsuyoshi Shirai Yoshinori Tanino Takefumi Nikaido Yotaro Takaku Seishu Hashimoto Yoshio Taguchi Tomohisa Baba Takashi Ogura Kensuke Kataoka Masayuki Nakayama Yoshihito Yamada Sayomi Matsushima Satoshi Nakayama Yasunari Miyazaki Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP® Allergology International Bird antigen Hypersensitivity pneumonitis ImmunoCAP® Screening Specific antigen |
author_facet |
Tsuyoshi Shirai Yoshinori Tanino Takefumi Nikaido Yotaro Takaku Seishu Hashimoto Yoshio Taguchi Tomohisa Baba Takashi Ogura Kensuke Kataoka Masayuki Nakayama Yoshihito Yamada Sayomi Matsushima Satoshi Nakayama Yasunari Miyazaki |
author_sort |
Tsuyoshi Shirai |
title |
Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP® |
title_short |
Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP® |
title_full |
Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP® |
title_fullStr |
Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP® |
title_full_unstemmed |
Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP® |
title_sort |
screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum igg and iga antibodies to bird antigens with immunocap® |
publisher |
Elsevier |
series |
Allergology International |
issn |
1323-8930 |
publishDate |
2021-04-01 |
description |
Background: Bird antigens are some of the most relevant antigens in hypersensitivity pneumonitis (HP). Possible sources of bird antigens are bird breeding, feather products and fertilizer with fowl droppings. For the screening and diagnosis of HP, the measurement of bird-specific antibodies should be standardized. The aim of this study was to clarify the utility of serum IgG (sIgG) and IgA (sIgA) antibodies to bird antigens in screening and diagnosing acute/chronic bird-related HP with ImmunoCAP® in multi-centre clinical research. Methods: We executed a clinical performance test by conducting a multi-institutional study to measure the levels of sIgG/sIgA against pigeon, parrot and budgerigar antigens by the ImmunoCAP® system in 29 acute and 46 chronic bird-related HP patients. Results: The levels of sIgG/sIgA against the bird antigens of the three species were significantly higher in subjects with acute bird-related HP and chronic bird-related HP with acute episodes (recurrent type) than in the control subjects. For sIgG, the optimal cutoff values by receiver operating characteristic (ROC) analysis were 24.6 mgA/L for pigeon, 14.0 mgA/L for parrot, and 8.7 mgA/L for budgerigar. By measuring multiple bird antigens and combining sIgG values of two species, the sensitivity and specificity for acute and recurrent-type chronic bird-related HP patients were 85–91% and 73–80%, respectively. For recurrent and insidious types of chronic bird-related HP, the sensitivity and specificity were 48–61% and 73–80%, respectively. Conclusions: Measurement of the levels of sIgG/sIgA against pigeon, budgerigar and parrot antigens by ImmunoCAP® was useful for screening and diagnosis in bird-related HP. |
topic |
Bird antigen Hypersensitivity pneumonitis ImmunoCAP® Screening Specific antigen |
url |
http://www.sciencedirect.com/science/article/pii/S1323893020301283 |
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