Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey
Summary: Background: Buruli ulcer is the third most common mycobacterial disease worldwide. The public health burden of this neglected tropical disease is large, particularly in poor areas of west and central Africa. The development of appropriate preventive strategies is hampered by an incomplete...
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doaj-f5751ee0157f4893be809bfe250530272020-11-25T02:04:48ZengElsevierThe Lancet Planetary Health2542-51962019-08-0138e349e356Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative surveyHorace Degnonvi, MS0Sebastien Fleuret, PhD1Clement Coudereau, PhD2Ronald Gnimavo, MD3Sigrid Giffon, MS4Edouard Yeramian, PhD5Roch Christian Johnson, PhD6Estelle Marion, PhD7Centre Inter Facultaire de Formation et de Recherche en Environnement pour le Développement Durable, Université d'Abomey Calavi, Cotonou, Benin; Centre de recherche en cancérologie et immunologie Nantes-Angers, French National Institute of Health and Medical Research, Université de Nantes, Université d'Angers, Angers, FranceCentre national de la recherche scientifique, UMR Espaces et SOciétés, Université d'Angers, Angers, FranceCentre de recherche en cancérologie et immunologie Nantes-Angers, French National Institute of Health and Medical Research, Université de Nantes, Université d'Angers, Angers, FranceCentre de Diagnostic et de Traitement de la lèpre et de l'ulcère de Buruli, Fondation Raoul Follereau, Pobè, BeninCentre national de la recherche scientifique, UMR Espaces et SOciétés, Université d'Angers, Angers, FranceUnité de microbiologie structurale, Institut Pasteur, Centre National de Recherche Scientifique, Université de Paris, Paris, FranceCentre Inter Facultaire de Formation et de Recherche en Environnement pour le Développement Durable, Université d'Abomey Calavi, Cotonou, BeninCentre de recherche en cancérologie et immunologie Nantes-Angers, French National Institute of Health and Medical Research, Université de Nantes, Université d'Angers, Angers, France; Correspondence to: Dr Estelle Marion, Centre de recherche en cancérologie et immunologie Nantes-Angers, French National Institute of Health and Medical Research, Université de Nantes, Université d'Angers, Angers 49000, FranceSummary: Background: Buruli ulcer is the third most common mycobacterial disease worldwide. The public health burden of this neglected tropical disease is large, particularly in poor areas of west and central Africa. The development of appropriate preventive strategies is hampered by an incomplete understanding of the epidemiology and transmission of the disease. We investigated the effect of the drilling of wells on Buruli ulcer incidence. Methods: In this case-control, quantitative survey, we obtained field data for Buruli ulcer incidence over a 10-year period from a specialised centre that collected data for the Ouémé and Plateau departments in Benin, and data for well drilling from the Ministry of Energy, Water and Mines in Benin. The coordinates of the wells drilled were obtained during site visits. A case-control study was then done to investigate the role of well water use in protecting against Buruli ulcer. Findings: We found a strong inverse correlation between the incidence of Buruli ulcer and the number of new wells drilled in the Bonou municipality (r2=0·8818). A case-control study (106 cases and 212 controls) showed that regular use of the water from the wells for washing, bathing, drinking, or cooking was protective against Buruli ulcer (adjusted odds ratio 0·1, 95% CI 0·04–0·44; p=0·0012). Interpretation: This study opens up new possibilities for developing an effective yet affordable policy to fight the disease on a substantial geographical scale. Our study shows that providing access to protected water is an efficient and feasable way to reduce the incidence of Buruli ulcer. Funding: Fondation Francaise Raoul Follereau, French National Institute of Health and Medical Research, and Région Pays de Loire.http://www.sciencedirect.com/science/article/pii/S254251961930110X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Horace Degnonvi, MS Sebastien Fleuret, PhD Clement Coudereau, PhD Ronald Gnimavo, MD Sigrid Giffon, MS Edouard Yeramian, PhD Roch Christian Johnson, PhD Estelle Marion, PhD |
spellingShingle |
Horace Degnonvi, MS Sebastien Fleuret, PhD Clement Coudereau, PhD Ronald Gnimavo, MD Sigrid Giffon, MS Edouard Yeramian, PhD Roch Christian Johnson, PhD Estelle Marion, PhD Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey The Lancet Planetary Health |
author_facet |
Horace Degnonvi, MS Sebastien Fleuret, PhD Clement Coudereau, PhD Ronald Gnimavo, MD Sigrid Giffon, MS Edouard Yeramian, PhD Roch Christian Johnson, PhD Estelle Marion, PhD |
author_sort |
Horace Degnonvi, MS |
title |
Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey |
title_short |
Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey |
title_full |
Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey |
title_fullStr |
Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey |
title_full_unstemmed |
Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey |
title_sort |
effect of well drilling on buruli ulcer incidence in benin: a case-control, quantitative survey |
publisher |
Elsevier |
series |
The Lancet Planetary Health |
issn |
2542-5196 |
publishDate |
2019-08-01 |
description |
Summary: Background: Buruli ulcer is the third most common mycobacterial disease worldwide. The public health burden of this neglected tropical disease is large, particularly in poor areas of west and central Africa. The development of appropriate preventive strategies is hampered by an incomplete understanding of the epidemiology and transmission of the disease. We investigated the effect of the drilling of wells on Buruli ulcer incidence. Methods: In this case-control, quantitative survey, we obtained field data for Buruli ulcer incidence over a 10-year period from a specialised centre that collected data for the Ouémé and Plateau departments in Benin, and data for well drilling from the Ministry of Energy, Water and Mines in Benin. The coordinates of the wells drilled were obtained during site visits. A case-control study was then done to investigate the role of well water use in protecting against Buruli ulcer. Findings: We found a strong inverse correlation between the incidence of Buruli ulcer and the number of new wells drilled in the Bonou municipality (r2=0·8818). A case-control study (106 cases and 212 controls) showed that regular use of the water from the wells for washing, bathing, drinking, or cooking was protective against Buruli ulcer (adjusted odds ratio 0·1, 95% CI 0·04–0·44; p=0·0012). Interpretation: This study opens up new possibilities for developing an effective yet affordable policy to fight the disease on a substantial geographical scale. Our study shows that providing access to protected water is an efficient and feasable way to reduce the incidence of Buruli ulcer. Funding: Fondation Francaise Raoul Follereau, French National Institute of Health and Medical Research, and Région Pays de Loire. |
url |
http://www.sciencedirect.com/science/article/pii/S254251961930110X |
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