A New Platinum-Based Prodrug Candidate for Chemotherapy and Its Synergistic Effect With Hadrontherapy: Novel Strategy to Treat Glioblastoma

A New Platinum-Based Prodrug Candidate for Chemotherapy and Its Synergistic Effect With Hadrontherapy: Novel Strategy to Treat Glioblastoma

Glioblastoma (GBM) is the most common tumor of the central nervous system. Current therapies, often associated with severe side effects, are inefficacious to contrast the GBM relapsing forms. In trying to overcome these drawbacks, (OC-6-44)-acetatodiamminedichlorido(2-(2-propynyl)octanoato)platinum(...

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Bibliographic Details
Main Authors: Beatrice Ferrari, Elisa Roda, Erica Cecilia Priori, Fabrizio De Luca, Angelica Facoetti, Mauro Ravera, Federico Brandalise, Carlo Alessandro Locatelli, Paola Rossi, Maria Grazia Bottone
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
platinum(IV) chemotherapeutics
hadrontherapy
carbon ions irradiation effects
tumor resistance
glioblastoma (GBM)
glioblastoma
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.589906/full

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