Immune-mediated chorea in a patient with kappa light-chain monoclonal gammopathy

• Main Authors: Amrita J Gotur, Roopa Rajan, Rishi Dhawan, Ajay Garg
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2020-01-01
• Series: Annals of Movement Disorders
• Subjects: chorea; immune-mediated; monoclonal gammopathy of undetermined significance; peripheral neuropathy
• Online Access: http://www.aomd.in/article.asp?issn=2590-3446;year=2020;volume=3;issue=2;spage=112;epage=114;aulast=Gotur

The objective of this paper was to report on a case of steroid-responsive chorea in a patient with κ light-chain monoclonal gammopathy. In addition to subacute-onset generalized chorea, evidence of peripheral neuropathy in this elderly gentleman led us to investigate for paraproteinemia. We treated the patient with intravenous steroids in view of elevated κ light-chain assay and bone marrow biopsy, suggestive of monoclonal gammopathy of undetermined significance. There was a remarkable improvement of paresthesias and chorea at 6 months follow-up with no evidence of evolution to malignancy at 1 year. Autoimmune chorea is a treatable condition if identified and treated timely.