Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites
Background/Aims: The aim of this study was to determine the optimal volume of peritoneal effusion required to diagnose malignant ascites. Patients and Methods: The authors recruited 123 patients with shifting dullness and obtained 123 peritoneocentesis fluid samples. The samples were divided into se...
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Wolters Kluwer Medknow Publications
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doaj-f57be8f9b2a3428a81233d0a13c5533f2020-11-24T21:20:55ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492019-01-0125532733210.4103/sjg.SJG_547_18Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascitesFeifei ZhangZhenning FengYichi ZhangZishuai LiuXiaoli SunShizhu JinBackground/Aims: The aim of this study was to determine the optimal volume of peritoneal effusion required to diagnose malignant ascites. Patients and Methods: The authors recruited 123 patients with shifting dullness and obtained 123 peritoneocentesis fluid samples. The samples were divided into seven aliquots of 10, 50, 100, 150, 200, 250, and 300 mL for cytopathological examination. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated for each aliquot. Results: The sensitivity for the diagnosis of malignant ascites gradually increased as the sample volume increased and reached a constant value at a volume of 200 mL. The sensitivity and NPV for the 10-, 100-, and 150-mL volumes were significantly different from those for the 200-mL sample. However, the sensitivity and NPV for the 250- and 300-mL volumes were not significantly different. The sensitivity for the diagnosis of malignant ascites is closely related to the volume of peritoneal fluid that is extracted by peritoneocentesis. Conclusion: We suggest a volume of 200 mL as the optimal minimum volume to confirm malignant ascites in patients with shifting dullness.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=5;spage=327;epage=332;aulast=ZhangDiagnosis of malignant ascitesnegative predictive valueoptimal volumeparaffin-embedded cell blockssensitivity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feifei Zhang Zhenning Feng Yichi Zhang Zishuai Liu Xiaoli Sun Shizhu Jin |
spellingShingle |
Feifei Zhang Zhenning Feng Yichi Zhang Zishuai Liu Xiaoli Sun Shizhu Jin Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites The Saudi Journal of Gastroenterology Diagnosis of malignant ascites negative predictive value optimal volume paraffin-embedded cell blocks sensitivity |
author_facet |
Feifei Zhang Zhenning Feng Yichi Zhang Zishuai Liu Xiaoli Sun Shizhu Jin |
author_sort |
Feifei Zhang |
title |
Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites |
title_short |
Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites |
title_full |
Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites |
title_fullStr |
Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites |
title_full_unstemmed |
Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites |
title_sort |
determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites |
publisher |
Wolters Kluwer Medknow Publications |
series |
The Saudi Journal of Gastroenterology |
issn |
1319-3767 1998-4049 |
publishDate |
2019-01-01 |
description |
Background/Aims: The aim of this study was to determine the optimal volume of peritoneal effusion required to diagnose malignant ascites.
Patients and Methods: The authors recruited 123 patients with shifting dullness and obtained 123 peritoneocentesis fluid samples. The samples were divided into seven aliquots of 10, 50, 100, 150, 200, 250, and 300 mL for cytopathological examination. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated for each aliquot.
Results: The sensitivity for the diagnosis of malignant ascites gradually increased as the sample volume increased and reached a constant value at a volume of 200 mL. The sensitivity and NPV for the 10-, 100-, and 150-mL volumes were significantly different from those for the 200-mL sample. However, the sensitivity and NPV for the 250- and 300-mL volumes were not significantly different. The sensitivity for the diagnosis of malignant ascites is closely related to the volume of peritoneal fluid that is extracted by peritoneocentesis.
Conclusion: We suggest a volume of 200 mL as the optimal minimum volume to confirm malignant ascites in patients with shifting dullness. |
topic |
Diagnosis of malignant ascites negative predictive value optimal volume paraffin-embedded cell blocks sensitivity |
url |
http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=5;spage=327;epage=332;aulast=Zhang |
work_keys_str_mv |
AT feifeizhang determinationoftheoptimalvolumeofasciticfluidfortheprecisediagnosisofmalignantascites AT zhenningfeng determinationoftheoptimalvolumeofasciticfluidfortheprecisediagnosisofmalignantascites AT yichizhang determinationoftheoptimalvolumeofasciticfluidfortheprecisediagnosisofmalignantascites AT zishuailiu determinationoftheoptimalvolumeofasciticfluidfortheprecisediagnosisofmalignantascites AT xiaolisun determinationoftheoptimalvolumeofasciticfluidfortheprecisediagnosisofmalignantascites AT shizhujin determinationoftheoptimalvolumeofasciticfluidfortheprecisediagnosisofmalignantascites |
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