Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

Summary: Constitutive expression of the immune checkpoint, PD-L1, inhibits anti-tumor immune responses in cancer, although the factors involved in PD-L1 regulation are poorly understood. Here we show that loss of global DNA methylation, particularly in intergenic regions and repeat elements, is asso...

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Bibliographic Details
Main Authors: Aniruddha Chatterjee, Euan J. Rodger, Antonio Ahn, Peter A. Stockwell, Matthew Parry, Jyoti Motwani, Stuart J. Gallagher, Elena Shklovskaya, Jessamy Tiffen, Michael R. Eccles, Peter Hersey
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300762

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