Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease susceptibility

• Main Authors: Tian-Biao Zhou, Sheng-Sheng Yin, Yuan-Han Qin
• Format: Article
• Language: English
• Published: Hindawi - SAGE Publishing 2014-03-01
• Series: Journal of the Renin-Angiotensin-Aldosterone System
• Online Access: https://doi.org/10.1177/1470320312460898

Background and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Results: Thirty-four articles were identified for the analysis of an association between ACE I/D gene polymorphism and ESRD risk. Both D allele and DD genotype were associated with ESRD susceptibility in overall populations (D: OR = 1.20, 95% CI: 1.06–1.36, p = 0.003, DD: OR = 1.47, 95% CI: 1.20–1.78, p = 0.0001) and in East Asians (D: OR = 1.34, 95% CI: 1.06–1.69, p = 0.01, DD: OR = 2.01, 95% CI: 1.29–3.12, p = 0.002). Only the DD genotype had a positive association with ESRD susceptibility in Caucasians (OR = 1.20, 95% CI: 1.01–1.43, p = 0.03). The result from sensitivity analysis in overall populations or Caucasians was similar to those in non-sensitivity analysis, but not among East Asians. Conclusions: The results of our study support the idea that D allele or DD genotype was associated with increased risk of ESRD susceptibility in the overall populations, and DD genotype was associated with ESRD susceptibility in Caucasians.