CSF p-Tau levels in the prediction of Alzheimer's disease
Summary The two hallmarks of Alzheimer's disease (AD) are neurofibrillary tangles and amyloid plaques. Neurofibrillary tangles are formed due to the hyperphosphorylation of tau protein. There is an urgent need to develop a reliable biomarker for the diagnosis of AD. Cerebrospinal fluid (CSF) is...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2013-09-01
|
Series: | Biology Open |
Subjects: | |
Online Access: | http://bio.biologists.org/content/2/11/1119 |
id |
doaj-f587af351d7c453f928d53b2087e9c35 |
---|---|
record_format |
Article |
spelling |
doaj-f587af351d7c453f928d53b2087e9c352021-06-02T14:57:13ZengThe Company of BiologistsBiology Open2046-63902013-09-012111119112410.1242/bio.2013544720135447CSF p-Tau levels in the prediction of Alzheimer's diseaseRamesh J. L. Kandimalla0Sudesh Prabhakar1Willayat Yousuf Wani2Alka Kaushal3Nidhi Gupta4Deep Raj Sharma5V. K. Grover6Neerja Bhardwaj7Kajal Jain8Kiran Dip Gill9 Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012 Summary The two hallmarks of Alzheimer's disease (AD) are neurofibrillary tangles and amyloid plaques. Neurofibrillary tangles are formed due to the hyperphosphorylation of tau protein. There is an urgent need to develop a reliable biomarker for the diagnosis of AD. Cerebrospinal fluid (CSF) is surrounding the brain and reflects the major neuropathological features in the AD brain. Diagnosis, disease progression and drug actions rely on the AD biomarkers. Mainly CSF tau and phosphorylated tau (p-Tau) have been observed to serve the purpose for early AD. Keeping in view the early appearance of p-Tau in CSF, we analyzed p-Tau levels in 23 AD, 23 Non AD type dementia (NAD), 23 Neurological control (NC) and 23 Healthy control (HC) North Indian patients. The levels of p-Tau were found to be increased in AD patients (67.87±18.05 pg/ml, SEM 3.76) compared with NAD (47.55±7.85 pg/ml, SEM 1.64), NC (34.42±4.51 pg/ml, SEM 0.94) and HC (27.09±7.18 pg/ml, SEM 1.50). The resulting sensitivity for AD with NAD was 80.27% whereas with respect to the NAD, NC and HC was 85.40%. Therefore elevated levels of p-Tau in AD can be exploited as a predictive biomarker in North Indian AD patients.http://bio.biologists.org/content/2/11/1119p-TauNorth Indian patientsSensitivityAlzheimer's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramesh J. L. Kandimalla Sudesh Prabhakar Willayat Yousuf Wani Alka Kaushal Nidhi Gupta Deep Raj Sharma V. K. Grover Neerja Bhardwaj Kajal Jain Kiran Dip Gill |
spellingShingle |
Ramesh J. L. Kandimalla Sudesh Prabhakar Willayat Yousuf Wani Alka Kaushal Nidhi Gupta Deep Raj Sharma V. K. Grover Neerja Bhardwaj Kajal Jain Kiran Dip Gill CSF p-Tau levels in the prediction of Alzheimer's disease Biology Open p-Tau North Indian patients Sensitivity Alzheimer's disease |
author_facet |
Ramesh J. L. Kandimalla Sudesh Prabhakar Willayat Yousuf Wani Alka Kaushal Nidhi Gupta Deep Raj Sharma V. K. Grover Neerja Bhardwaj Kajal Jain Kiran Dip Gill |
author_sort |
Ramesh J. L. Kandimalla |
title |
CSF p-Tau levels in the prediction of Alzheimer's disease |
title_short |
CSF p-Tau levels in the prediction of Alzheimer's disease |
title_full |
CSF p-Tau levels in the prediction of Alzheimer's disease |
title_fullStr |
CSF p-Tau levels in the prediction of Alzheimer's disease |
title_full_unstemmed |
CSF p-Tau levels in the prediction of Alzheimer's disease |
title_sort |
csf p-tau levels in the prediction of alzheimer's disease |
publisher |
The Company of Biologists |
series |
Biology Open |
issn |
2046-6390 |
publishDate |
2013-09-01 |
description |
Summary
The two hallmarks of Alzheimer's disease (AD) are neurofibrillary tangles and amyloid plaques. Neurofibrillary tangles are formed due to the hyperphosphorylation of tau protein. There is an urgent need to develop a reliable biomarker for the diagnosis of AD. Cerebrospinal fluid (CSF) is surrounding the brain and reflects the major neuropathological features in the AD brain. Diagnosis, disease progression and drug actions rely on the AD biomarkers. Mainly CSF tau and phosphorylated tau (p-Tau) have been observed to serve the purpose for early AD. Keeping in view the early appearance of p-Tau in CSF, we analyzed p-Tau levels in 23 AD, 23 Non AD type dementia (NAD), 23 Neurological control (NC) and 23 Healthy control (HC) North Indian patients. The levels of p-Tau were found to be increased in AD patients (67.87±18.05 pg/ml, SEM 3.76) compared with NAD (47.55±7.85 pg/ml, SEM 1.64), NC (34.42±4.51 pg/ml, SEM 0.94) and HC (27.09±7.18 pg/ml, SEM 1.50). The resulting sensitivity for AD with NAD was 80.27% whereas with respect to the NAD, NC and HC was 85.40%. Therefore elevated levels of p-Tau in AD can be exploited as a predictive biomarker in North Indian AD patients. |
topic |
p-Tau North Indian patients Sensitivity Alzheimer's disease |
url |
http://bio.biologists.org/content/2/11/1119 |
work_keys_str_mv |
AT rameshjlkandimalla csfptaulevelsinthepredictionofalzheimersdisease AT sudeshprabhakar csfptaulevelsinthepredictionofalzheimersdisease AT willayatyousufwani csfptaulevelsinthepredictionofalzheimersdisease AT alkakaushal csfptaulevelsinthepredictionofalzheimersdisease AT nidhigupta csfptaulevelsinthepredictionofalzheimersdisease AT deeprajsharma csfptaulevelsinthepredictionofalzheimersdisease AT vkgrover csfptaulevelsinthepredictionofalzheimersdisease AT neerjabhardwaj csfptaulevelsinthepredictionofalzheimersdisease AT kajaljain csfptaulevelsinthepredictionofalzheimersdisease AT kirandipgill csfptaulevelsinthepredictionofalzheimersdisease |
_version_ |
1721403437875200000 |